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Nudt2 nudix hydrolase 2 [ Mus musculus (house mouse) ]

Gene ID: 66401, updated on 5-Mar-2024

Summary

Official Symbol
Nudt2provided by MGI
Official Full Name
nudix hydrolase 2provided by MGI
Primary source
MGI:MGI:1913651
See related
Ensembl:ENSMUSG00000028443 AllianceGenome:MGI:1913651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APAH1; 2310051L06Rik
Summary
Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process; ATP biosynthetic process; and apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 14.1), placenta adult (RPKM 10.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 A5; 4 21.65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41465085..41480926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41465081..41480926)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:41295845-41296146 Neighboring gene ubiquitin-associated protein 1 Neighboring gene kinesin family member 24 Neighboring gene STARR-seq mESC enhancer starr_10033 Neighboring gene STARR-positive B cell enhancer ABC_E277 Neighboring gene STARR-seq mESC enhancer starr_10034 Neighboring gene myogenesis regulating glycosidase (putative) Neighboring gene sperm microtubule inner protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ATP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Names
ap4A hydrolase
ap4Aase
bis(5'-nucleosyl)-tetraphosphatase
diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
diadenosine tetraphosphatase
nucleoside diphosphate-linked moiety X motif 2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
nudix motif 2
NP_079815.2
XP_006538228.1
XP_011248384.1
XP_030109557.1
XP_036020201.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025539.2NP_079815.2  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

    See identical proteins and their annotated locations for NP_079815.2

    Status: VALIDATED

    Source sequence(s)
    AK018771, AK132532, CB845734
    Consensus CDS
    CCDS18061.1
    UniProtKB/Swiss-Prot
    P56380, Q9D2U6, Q9D6V2
    UniProtKB/TrEMBL
    Q3V1C8
    Related
    ENSMUSP00000030154.7, ENSMUST00000030154.7
    Conserved Domains (1) summary
    cd03428
    Location:2140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41465085..41480926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164308.1XP_036020201.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    UniProtKB/Swiss-Prot
    P56380, Q9D2U6, Q9D6V2
    UniProtKB/TrEMBL
    Q3V1C8
    Conserved Domains (1) summary
    cd03428
    Location:2140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
  2. XM_011250082.4XP_011248384.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    See identical proteins and their annotated locations for XP_011248384.1

    UniProtKB/Swiss-Prot
    P56380, Q9D2U6, Q9D6V2
    UniProtKB/TrEMBL
    Q3V1C8
    Conserved Domains (1) summary
    cd03428
    Location:2140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
  3. XM_030253697.2XP_030109557.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    UniProtKB/Swiss-Prot
    P56380, Q9D2U6, Q9D6V2
    UniProtKB/TrEMBL
    Q3V1C8
    Conserved Domains (1) summary
    cd03428
    Location:2140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
  4. XM_006538165.4XP_006538228.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    See identical proteins and their annotated locations for XP_006538228.1

    UniProtKB/Swiss-Prot
    P56380, Q9D2U6, Q9D6V2
    UniProtKB/TrEMBL
    Q3V1C8
    Conserved Domains (1) summary
    cd03428
    Location:2140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...