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Gmpr guanosine monophosphate reductase [ Mus musculus (house mouse) ]

Gene ID: 66355, updated on 5-Mar-2024

Summary

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Official Symbol
Gmprprovided by MGI
Official Full Name
guanosine monophosphate reductaseprovided by MGI
Primary source
MGI:MGI:1913605
See related
Ensembl:ENSMUSG00000000253 AllianceGenome:MGI:1913605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GMPR 1; 2310004P21Rik
Summary
A similar gene in human encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. [provided by RefSeq, May 2015]
Expression
Broad expression in liver E14 (RPKM 82.5), liver E14.5 (RPKM 79.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 21.94 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (45660905..45699862)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (45507428..45546386)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1462 Neighboring gene STARR-seq mESC enhancer starr_34393 Neighboring gene STARR-positive B cell enhancer ABC_E5392 Neighboring gene myosin regulatory light chain interacting protein Neighboring gene predicted gene, 53792 Neighboring gene STARR-positive B cell enhancer ABC_E7232 Neighboring gene STARR-seq mESC enhancer starr_34395 Neighboring gene predicted gene, 34582 Neighboring gene ataxin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr13:45744500-45744801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:45789016-45789125 Neighboring gene STARR-seq mESC enhancer starr_34397 Neighboring gene STARR-seq mESC enhancer starr_34398 Neighboring gene STARR-positive B cell enhancer mm9_chr13:45980000-45980300 Neighboring gene STARR-seq mESC enhancer starr_34399 Neighboring gene STARR-positive B cell enhancer mm9_chr13:46017736-46018037 Neighboring gene RIKEN cDNA 5033430I15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr13:46060268-46060569

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes. Hedstrom L. Crit Rev Biochem Mol Biol, 2012 May-Jun. PMID 22332716, Free PMC Article
  2. Guanosine 5'-phosphate reductase and its role in the interconversion of purine nucleotides. MAGER J, et al. J Biol Chem, 1960 May. PMID 14419794
  3. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. Lai HC, et al. J Neurosci, 2011 Jul 27. PMID 21795538, Free PMC Article
  4. Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Pang CJ, et al. Mol Cell Biol, 2012 Jul. PMID 22566683, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GMP reductase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IMP salvage ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GMP reductase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GMP reductase 1
Names
guanosine 5'-monophosphate oxidoreductase 1
guanosine monophosphate reductase 1
NP_079784.1
XP_017171050.1
XP_017171051.1
XP_030103212.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025508.5 → NP_079784.1  GMP reductase 1

    See identical proteins and their annotated locations for NP_079784.1

    Status: REVIEWED

    Source sequence(s)
    AC154521, AC154817, AK084508, BY274415
    Consensus CDS
    CCDS26482.1
    UniProtKB/Swiss-Prot
    Q9DCZ1
    Related
    ENSMUSP00000000260.6, ENSMUST00000000260.13
    Conserved Domains (2) summary
    TIGR01305
    Location:3 → 344
    GMP_reduct_1; guanosine monophosphate reductase, eukaryotic
    cd00381
    Location:10 → 336
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    45660905..45699862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247352.2 → XP_030103212.1  GMP reductase 1 isoform X1

    Conserved Domains (1) summary
    PRK05096
    Location:3 → 393
    PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

  2. XM_017315562.1 → XP_017171051.1  GMP reductase 1 isoform X3

    UniProtKB/TrEMBL
    F6VY18
    Conserved Domains (1) summary
    TIGR01305
    Location:1 → 290
    GMP_reduct_1; guanosine monophosphate reductase, eukaryotic

  3. XM_017315561.1 → XP_017171050.1  GMP reductase 1 isoform X2

    Conserved Domains (1) summary
    PRK05096
    Location:30 → 278
    PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCZ1.1 GenPept UniProtKB/Swiss-Prot:Q9DCZ1

Gene LinkOut

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