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Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [ Mus musculus (house mouse) ]

Gene ID: 66094, updated on 11-Apr-2024

Summary

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Official Symbol
Lsm7provided by MGI
Official Full Name
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by MGI
Primary source
MGI:MGI:1913344
See related
Ensembl:ENSMUSG00000035215 AllianceGenome:MGI:1913344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0910001B06Rik; 1110033F18Rik
Summary
Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of several cellular components, including Lsm1-7-Pat1 complex; spliceosomal complex; and spliceosomal snRNP complex. Is expressed in central nervous system and sensory organ. Orthologous to human LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.2), liver E14 (RPKM 73.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lsm7 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80688659..80691043, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80852825..80855209, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 1982 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E11447 Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene signal peptide peptidase like 2B Neighboring gene transmembrane protease, serine 9 Neighboring gene translocase of inner mitochondrial membrane 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role for LSM genes in the regulation of circadian rhythms. Perez-Santángelo S, et al. Proc Natl Acad Sci U S A, 2014 Oct 21. PMID 25288739, Free PMC Article
  2. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Kim J, et al. Mol Cell Biol, 2020 Oct 13. PMID 32839293, Free PMC Article
  3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Lsm2-8 complex ISO
Inferred from Sequence Orthology
more info
  
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
U6 snRNA-associated Sm-like protein LSm7
Names
LSM7 homolog, U6 small nuclear RNA associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359148.1 → NP_001346077.1  U6 snRNA-associated Sm-like protein LSm7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166937, AK013355, BC027511
    Conserved Domains (1) summary
    cd01729
    Location:10 → 98
    LSm7; Like-Sm protein 7

  2. NM_001359149.1 → NP_001346078.1  U6 snRNA-associated Sm-like protein LSm7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166937, AK013355, BC027511
    Conserved Domains (1) summary
    cd01729
    Location:20 → 108
    LSm7; Like-Sm protein 7

  3. NM_001359150.1 → NP_001346079.1  U6 snRNA-associated Sm-like protein LSm7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166937, AK013355, BC027511
    Related
    ENSMUST00000220406.2
    Conserved Domains (1) summary
    cd01729
    Location:21 → 107
    LSm7; Like-Sm protein 7

  4. NM_025349.2 → NP_079625.1  U6 snRNA-associated Sm-like protein LSm7 isoform 4

    See identical proteins and their annotated locations for NP_079625.1

    Status: VALIDATED

    Source sequence(s)
    AK013355, BC027511
    Consensus CDS
    CCDS35987.1
    UniProtKB/Swiss-Prot
    Q9CQQ8
    Related
    ENSMUSP00000044993.9, ENSMUST00000035775.9
    Conserved Domains (1) summary
    cd01729
    Location:9 → 97
    LSm7; Like-Sm protein 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80688659..80691043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQQ8.1 GenPept UniProtKB/Swiss-Prot:Q9CQQ8

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