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Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein [ Mus musculus (house mouse) ]

Gene ID: 66052, updated on 11-Apr-2024

Summary

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Official Symbol
Sdhcprovided by MGI
Official Full Name
succinate dehydrogenase complex, subunit C, integral membrane proteinprovided by MGI
Primary source
MGI:MGI:1913302
See related
Ensembl:ENSMUSG00000058076 AllianceGenome:MGI:1913302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610010E03Rik
Summary
Predicted to enable electron transfer activity; metal ion binding activity; and succinate dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to act upstream of or within tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 368.5), kidney adult (RPKM 283.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sdhc in Genome Data Viewer
Location:
1 H3; 1 78.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170956726..170978209, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171129157..171150640, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2017 Neighboring gene nuclear encoded tRNA valine 6 (anticodon CAC) Neighboring gene STARR-positive B cell enhancer ABC_E222 Neighboring gene cilia and flagella associated protein 126 Neighboring gene STARR-seq mESC enhancer starr_03017 Neighboring gene predicted gene, 46172 Neighboring gene STARR-positive B cell enhancer ABC_E2018 Neighboring gene myelin protein zero Neighboring gene Purkinje cell protein 4-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema. Balnis J, et al. Am J Respir Cell Mol Biol, 2021 Sep. PMID 33909984, Free PMC Article
  2. Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain. Ishii T, et al. Aging Cell, 2017 Feb. PMID 27623715, Free PMC Article
  3. Oxygen concentration controls epigenetic effects in models of familial paraganglioma. Her YF, et al. PLoS One, 2015. PMID 25985299, Free PMC Article
  4. The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. Albayrak T, et al. Mol Biol Cell, 2003 Aug. PMID 12925748, Free PMC Article
  5. Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Paddenberg R, et al. Am J Physiol Lung Cell Mol Physiol, 2003 May. PMID 12676762

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.
    Title: SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.
  2. Studies indicate that the Tet-mev-1 conditional transgenic system can induce mutated SDHC gene in complex II.
    Title: Model animals for the study of oxidative stress from complex II.
  3. a sensor for apoptosis induction
    Title: The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction.
  4. complex II plays an essential role in hypoxic reactive oxygen species production.
    Title: Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103103

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in tricarboxylic acid cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of succinate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of succinate dehydrogenase complex (ubiquinone) IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Names
QPs-1
QPs1
integral membrane protein CII-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025321.3 → NP_079597.2  succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079597.2

    Status: VALIDATED

    Source sequence(s)
    AK002459, AV356234, BY711932
    Consensus CDS
    CCDS35772.1
    UniProtKB/Swiss-Prot
    Q544Q9, Q99JP2, Q9CZB0, Q9DCU7
    UniProtKB/TrEMBL
    Q5XK33
    Related
    ENSMUSP00000106968.4, ENSMUST00000111336.10
    Conserved Domains (1) summary
    cd03499
    Location:50 → 152
    SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170956726..170978209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496955.3 → XP_006497018.2  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q5XK33
    Conserved Domains (1) summary
    cd03499
    Location:31 → 133
    SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...

  2. XM_030241961.1 → XP_030097821.1  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2

    UniProtKB/TrEMBL
    F8WGB3
    Conserved Domains (1) summary
    cd03499
    Location:13 → 115
    SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZB0.1 GenPept UniProtKB/Swiss-Prot:Q9CZB0

Gene LinkOut

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