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CYP4F12 cytochrome P450 family 4 subfamily F member 12 [ Homo sapiens (human) ]

Gene ID: 66002, updated on 5-Mar-2024

Summary

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Official Symbol
CYP4F12provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 12provided by HGNC
Primary source
HGNC:HGNC:18857
See related
Ensembl:ENSG00000186204 MIM:611485; AllianceGenome:HGNC:18857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPIVF12; F22329_1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Biased expression in small intestine (RPKM 23.2), duodenum (RPKM 22.3) and 10 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15673087..15697174)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15798486..15822059)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15783897..15807984)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily F member 3 Neighboring gene cytochrome P450 family 4 subfamily F member 10, pseudogene Neighboring gene olfactory receptor family 10 subfamily H member 2 Neighboring gene olfactory receptor family 10 subfamily H member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway. Jia W, et al. Sci Rep, 2023 Jul 6. PMID 37414830, Free PMC Article
  2. Genetic variants of CYP4F12 gene are associated with glioma susceptibility. Li N, et al. Int J Cancer, 2021 Dec 1. PMID 34319593
  3. Distinction between human cytochrome P450 (CYP) isoforms and identification of new phosphorylation sites by mass spectrometry. Redlich G, et al. J Proteome Res, 2008 Nov. PMID 18828626
  4. Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymes. Cauffiez C, et al. Biochem Pharmacol, 2004 Dec 15. PMID 15548388
  5. Expression and induction of CYP4F subfamily in human leukocytes and HL60 cells. Kikuta Y, et al. Biochim Biophys Acta, 2004 Jul 5. PMID 15238214

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway.
    Title: CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway.
  2. Genetic variants of CYP4F12 gene are associated with glioma susceptibility.
    Title: Genetic variants of CYP4F12 gene are associated with glioma susceptibility.
  3. These results suggest that human and marmoset P450 3A4/90 and 4F12 in livers or small intestines played important roles in terfenadine t-butyl hydroxylation. Marmosets could be a model for humans during first pass extraction of terfenadine and related substrates.
    Title: Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines.
  4. Our results showed that HCV infection induced expression of CYP4F12 protein, which bound to the HCV replication complex to facilitate viral replication.
    Title: Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B.
  5. 3-hydroxystearate and 3-hydroxypalmitate are converted to omega-hydroxylated 3-OHDCA precursors in liver; CYP4F11 and, to a lesser extent, CYP4F2 catalyzed omega-hydroxylation of 3-hydroxystearate; CYP4F3b, CYP4F12, and CYP4A11 had negligible activity.
    Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.
  6. We conclude that CYP4F8 and CYP4F12 catalyze epoxidation of 22:6n-3 and 22:5n-3, and CYP4F8 omega3-hydroxylation of 22:5n-6.
    Title: Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alkane 1-monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables arachidonic acid epoxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-B4 20-monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables monooxygenase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epoxygenase P450 pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
  
involved_in leukotriene B4 catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in menaquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phylloquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pressure natriuresis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in renal water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in very long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vitamin E metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome P450 4F12
Names
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, subfamily IVF, polypeptide 12
NP_076433.3
XP_006722913.1
XP_011526504.1
XP_011526506.1
XP_011526507.1
XP_011526509.1
XP_011526510.1
XP_016882661.1
XP_054177808.1
XP_054177809.1
XP_054177810.1
XP_054177811.1
XP_054177812.1
XP_054177813.1
XP_054177814.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008336.2 RefSeqGene

    Range
    5012..29099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_023944.4 → NP_076433.3  cytochrome P450 4F12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
    Source sequence(s)
    AB035130, AC122702, DC418592, DR422336
    Consensus CDS
    CCDS42517.1
    UniProtKB/Swiss-Prot
    E7ET51, O60389, Q5JPJ7, Q9HCS1, Q9HCS2
    UniProtKB/TrEMBL
    Q8IV39
    Related
    ENSP00000448998.1, ENST00000550308.6
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 506
    p450; Cytochrome P450

RNA

  1. NR_117085.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and contains two additional internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB035130, AC122702, AK075435, BC034916, DC418592, DR422336
    Related
    ENST00000518629.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    15673087..15697174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027172.2 → XP_016882661.1  cytochrome P450 4F12 isoform X1

  2. XM_011528208.3 → XP_011526510.1  cytochrome P450 4F12 isoform X2

    See identical proteins and their annotated locations for XP_011526510.1

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 357
    p450; Cytochrome P450

  3. XM_006722850.4 → XP_006722913.1  cytochrome P450 4F12 isoform X2

    See identical proteins and their annotated locations for XP_006722913.1

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 357
    p450; Cytochrome P450

  4. XM_011528202.4 → XP_011526504.1  cytochrome P450 4F12 isoform X2

    See identical proteins and their annotated locations for XP_011526504.1

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 357
    p450; Cytochrome P450

  5. XM_011528205.3 → XP_011526507.1  cytochrome P450 4F12 isoform X3

    See identical proteins and their annotated locations for XP_011526507.1

    Conserved Domains (1) summary
    pfam00067
    Location:4 → 334
    p450; Cytochrome P450

  6. XM_011528207.3 → XP_011526509.1  cytochrome P450 4F12 isoform X4

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 316
    p450; Cytochrome P450

  7. XM_011528204.3 → XP_011526506.1  cytochrome P450 4F12 isoform X3

    See identical proteins and their annotated locations for XP_011526506.1

    Conserved Domains (1) summary
    pfam00067
    Location:4 → 334
    p450; Cytochrome P450

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    15798486..15822059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321833.1 → XP_054177808.1  cytochrome P450 4F12 isoform X1

  2. XM_054321839.1 → XP_054177814.1  cytochrome P450 4F12 isoform X2

  3. XM_054321834.1 → XP_054177809.1  cytochrome P450 4F12 isoform X2

  4. XM_054321835.1 → XP_054177810.1  cytochrome P450 4F12 isoform X2

  5. XM_054321837.1 → XP_054177812.1  cytochrome P450 4F12 isoform X3

  6. XM_054321838.1 → XP_054177813.1  cytochrome P450 4F12 isoform X4

  7. XM_054321836.1 → XP_054177811.1  cytochrome P450 4F12 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCS2.3 GenPept UniProtKB/Swiss-Prot:Q9HCS2

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