cxcr3.1 chemokine (C-X-C motif) receptor 3, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cxcr3.1provided by ZNC
Official Full Name: chemokine (C-X-C motif) receptor 3, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060130-38
See related: Ensembl:ENSDARG00000007358 AllianceGenome:ZFIN:ZDB-GENE-060130-38
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu378
Summary: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; angiogenesis; and regulation of leukocyte migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif chemokine receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (11853457..11859309, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (11962554..11981283, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system.
Title: The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 3.1

Names: CXCR3ab; chemokine (C-X-C motif) receptor 3.1; dr-chr16-CXCR3-41.8-EK27498

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089430.2 → NP_001082899.2 C-X-C chemokine receptor type 3.1

Status: VALIDATED

Source sequence(s)

BC139525

UniProtKB/TrEMBL

A0A8M1NCV2, A4QNU5, F1Q6R0

Related

ENSDARP00000115748.1, ENSDART00000145754.2

Conserved Domains (1) summary

pfam00001
Location:65 → 319

7tm_1; 7 transmembrane receptor (rhodopsin family)