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Trnau1ap tRNA selenocysteine 1 associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65241, updated on 2-May-2024

Summary

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Official Symbol
Trnau1approvided by RGD
Official Full Name
tRNA selenocysteine 1 associated protein 1provided by RGD
Primary source
RGD:619995
See related
Ensembl:ENSRNOG00000055344 AllianceGenome:RGD:619995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Secp43; Trspap1
Summary
Enables tRNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRNAU1AP (tRNA selenocysteine 1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 246.5), Muscle (RPKM 191.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149791631..149808149, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144507044..144524142, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150463797..150506803, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102992 Neighboring gene small nucleolar RNA, H/ACA box 61 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene regulator of chromosome condensation 1 Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene phosphatase and actin regulator 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells. Li MD, et al. Mol Med Rep, 2017 Feb. PMID 28101579
  2. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. Ding F, et al. RNA, 1999 Dec. PMID 10606267, Free PMC Article
  3. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. Xu XM, et al. J Biol Chem, 2005 Dec 16. PMID 16230358
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of Trnau1ap inhibits the proliferation of cardiomyocytelike H9c2 cells. Downregulation of Trnau1ap induces apoptosis.
    Title: Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in selenocysteine incorporation ISO
Inferred from Sequence Orthology
more info
  
involved_in selenocysteine incorporation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA selenocysteine 1-associated protein 1
Names
tRNA selenocysteine 1-associated protein 1-like
tRNA selenocysteine associated protein
tRNA selenocysteine-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411667.1 → NP_001398596.1  tRNA selenocysteine 1-associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6A7J2
    Related
    ENSRNOP00000088939.1, ENSRNOT00000102379.1

  2. NM_001411668.1 → NP_001398597.1  tRNA selenocysteine 1-associated protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  3. NM_001411669.1 → NP_001398598.1  tRNA selenocysteine 1-associated protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  4. NM_001411670.1 → NP_001398599.1  tRNA selenocysteine 1-associated protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  5. NM_001411671.1 → NP_001398600.1  tRNA selenocysteine 1-associated protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  6. NM_001411672.1 → NP_001398601.1  tRNA selenocysteine 1-associated protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  7. NM_001411673.1 → NP_001398602.1  tRNA selenocysteine 1-associated protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  8. NM_001411674.1 → NP_001398603.1  tRNA selenocysteine 1-associated protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  9. NM_023027.2 → NP_075416.1  tRNA selenocysteine 1-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_075416.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q9QZI7
    UniProtKB/TrEMBL
    A0A0G2JZ46
    Related
    ENSRNOP00000084120.1, ENSRNOT00000113510.1
    Conserved Domains (3) summary
    pfam17654
    Location:205 → 284
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cd12610
    Location:4 → 87
    RRM1_SECp43; RNA recognition motif 1 (RRM1) found in tRNA selenocysteine-associated protein 1 (SECp43)
    cd12612
    Location:95 → 176
    RRM2_SECp43; RNA recognition motif 2 (RRM2) found in tRNA selenocysteine-associated protein 1 (SECp43)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    149791631..149808149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110739.2 → XP_038966667.1  tRNA selenocysteine 1-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    A6ISS5
    Conserved Domains (2) summary
    pfam17654
    Location:70 → 149
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cl17169
    Location:4 → 42
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_039110734.2 → XP_038966662.1  tRNA selenocysteine 1-associated protein 1 isoform X1

    Conserved Domains (3) summary
    pfam17654
    Location:205 → 242
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cd12610
    Location:4 → 87
    RRM1_SECp43; RNA recognition motif 1 (RRM1) found in tRNA selenocysteine-associated protein 1 (SECp43)
    cd12612
    Location:95 → 176
    RRM2_SECp43; RNA recognition motif 2 (RRM2) found in tRNA selenocysteine-associated protein 1 (SECp43)

  3. XM_039110736.2 → XP_038966664.1  tRNA selenocysteine 1-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZ46
    Conserved Domains (3) summary
    pfam17654
    Location:161 → 240
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cd12610
    Location:4 → 87
    RRM1_SECp43; RNA recognition motif 1 (RRM1) found in tRNA selenocysteine-associated protein 1 (SECp43)
    cl17169
    Location:93 → 132
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_063288370.1 → XP_063144440.1  tRNA selenocysteine 1-associated protein 1 isoform X4

RNA

  1. XR_005504536.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZI7.1 GenPept UniProtKB/Swiss-Prot:Q9QZI7

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