mapk8b mitogen-activated protein kinase 8b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mapk8bprovided by ZNC
Official Full Name: mitogen-activated protein kinase 8bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010202-1
See related: Ensembl:ENSDARG00000009870 AllianceGenome:ZFIN:ZDB-GENE-010202-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: JNK; JNK1; jnk1b; mapk8; jnk1a-1; zgc:112379
Summary: Predicted to enable JUN kinase activity. Involved in JNK cascade and determination of dorsal identity. Predicted to be located in synapse. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; gut; head; pectoral fin; and pericardial region. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (2499698..2522550, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (2464965..2487810, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results found that jnk1a is required for morphogenesis of the first heart field (FHF) ventricular component, and highlight the importance of alternative splicing in vertebrate cardiac morphogenesis.
Title: Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression.
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
Title: JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes.
P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Title: P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
JNK-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Title: In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury.
A dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis, is defined.
Title: A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitogen-activated protein kinase 8

Names: MAP kinase 8; MAPK 8; c-Jun N-terminal kinase 1; stress-activated protein kinase JNK1

NP_571796.1

EC 2.7.11.24

XP_017213974.1

EC 2.7.11.24

XP_017213975.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131721.2 → NP_571796.1 mitogen-activated protein kinase 8

See identical proteins and their annotated locations for NP_571796.1

Status: VALIDATED

Source sequence(s)

CR774192

UniProtKB/Swiss-Prot

Q9DGD9

Related

ENSDARP00000012611.9, ENSDART00000022471.11

Conserved Domains (2) summary

smart00220
Location:26 → 321

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase