Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2j4provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily j, polypeptide 4provided by RGD
Primary source: RGD:620007
See related: Ensembl:ENSRNOG00000031004 AllianceGenome:RGD:620007
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYP2J2; CYPIIJ4
Summary: Enables NADPH-hemoprotein reductase activity and arachidonic acid monooxygenase activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and positive regulation of tumor necrosis factor production. Located in endoplasmic reticulum membrane. Used to study nephritis; pre-eclampsia; and ureteral obstruction. Biomarker of bacterial pneumonia and renal hypertension. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 211.9), Kidney (RPKM 55.2) and 7 other tissues See more
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Genomic context

Location:: 5q33

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (116295691..116323219, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (111179981..111207490, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (119546458..119564843, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP2J deficiency leads to cardiac injury and presents dual regulatory effects on cardiac function in rats.
Title: CYP2J deficiency leads to cardiac injury and presents dual regulatory effects on cardiac function in rats.
Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
Title: Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
Our findings demonstrate that CYP2J2 improves cardiac function by increasing the concentration of circulating EETs, and boosting angiogenesis via the Jagged1/Notch1 signaling pathway in MI-induced heart failure.
Title: Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
the N-terminus of CYP2J2 is very important to form a productive CYP-CPR complex to facilitate electron transfer.
Title: CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR.
Data indicate that cytochrome P450 epoxygenase 2J2 (CYP2J2) overexpression markedly decreased the levels of oxidative stress and cell apoptosis in lung tissues induced by ischemia/reperfusion.
Title: CYP2J2 and EETs Protect against Oxidative Stress and Apoptosis in Vivo and in Vitro Following Lung Ischemia/Reperfusion.
Reduced in a rat model of acute Pseudomonas pneumonia.
Title: Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia.
inhibition of iNOS restores CYP2J4 protein content and CYP activity in acute pneumonia, indicating an important NO-CYP interaction in pulmonary responses to infection
Title: Excess nitric oxide decreases cytochrome P-450 2J4 content and P-450-dependent arachidonic acid metabolism in lungs of rats with acute pneumonia.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADPH-hemoprotein reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid 11,12-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid 14,15-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	ISO Inferred from Sequence Orthology more info
enables linoleic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in epoxygenase P450 pathway	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2J4

NP_075414.2

EC 1.14.14.1

XP_038966661.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023025.2 → NP_075414.2 cytochrome P450 2J4

See identical proteins and their annotated locations for NP_075414.2

Status: PROVISIONAL

Source sequence(s)

BC091149

UniProtKB/Swiss-Prot

Q9QXF7

UniProtKB/TrEMBL

A0A9K3Y868, F7FF10, Q5BKA2

Related

ENSRNOP00000012977.6, ENSRNOT00000012977.6

Conserved Domains (1) summary

pfam00067
Location:44 → 496

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

116295691..116323219 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110733.2 → XP_038966661.1 cytochrome P450 2J4 isoform X1

Conserved Domains (1) summary

cl41757
Location:75 → 396

cytochrome_P450; cytochrome P450 (CYP) superfamily