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Mmp16 matrix metallopeptidase 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65205, updated on 13-Apr-2024

Summary

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Official Symbol
Mmp16provided by RGD
Official Full Name
matrix metallopeptidase 16provided by RGD
Primary source
RGD:620199
See related
Ensembl:ENSRNOG00000005708 AllianceGenome:RGD:620199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mt3-mmp
Summary
Predicted to enable metalloaminopeptidase activity; metalloendopeptidase activity; and zinc ion binding activity. Involved in response to odorant. Predicted to be located in extracellular matrix and extracellular region. Predicted to be integral component of plasma membrane. Orthologous to human MMP16 (matrix metallopeptidase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 92.7), Lung (RPKM 49.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (36109265..36353252)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (31312280..31556276)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (31568344..31818368)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5, pseudogene 9 Neighboring gene U6 spliceosomal RNA Neighboring gene U7 small nuclear RNA Neighboring gene transfer RNA proline (anticodon AGG) 53

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biochemical and spectroscopic characterization of the catalytic domain of MMP16 (cdMMP16). Meng F, et al. J Biol Inorg Chem, 2016 Jul. PMID 27229514
  2. Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain. Shofuda K, et al. J Biol Chem, 1997 Apr 11. PMID 9092507
  3. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. Takino T, et al. J Biol Chem, 1995 Sep 29. PMID 7559440
  4. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. Hadchouel A, et al. PLoS One, 2008 Sep 11. PMID 18784838, Free PMC Article
  5. Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis. Shi J, et al. Dev Biol, 2008 Jan 1. PMID 18022611, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MMP16 polymorphisms appear to influence not only the pulmonary expression and function of MMP16 but also the risk of bronchopulmonary dysplasia
    Title: Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within collagen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in craniofacial suture morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within craniofacial suture morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in endochondral ossification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endochondral ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to odorant IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-16
Names
MMP-16
MT-MMP 3
MT3MMP
MTMMP3
membrane-type matrix metalloproteinase 3
membrane-type-3 matrix metalloproteinase
NP_542954.2
XP_038966660.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080776.4 → NP_542954.2  matrix metalloproteinase-16 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    O35541, O35548
    UniProtKB/TrEMBL
    A6IIB9, F1M7F5
    Related
    ENSRNOP00000040229.6, ENSRNOT00000050137.6
    Conserved Domains (5) summary
    PHA03247
    Location:292 → 338
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:340 → 532
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:126 → 291
    Peptidase_M10; Matrixin
    pfam01471
    Location:46 → 96
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:537 → 607
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    36109265..36353252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110732.2 → XP_038966660.1  matrix metalloproteinase-16 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:29 → 75
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:77 → 269
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:1 → 28
    Peptidase_M10; Matrixin
    pfam11857
    Location:274 → 344
    DUF3377; Domain of unknown function (DUF3377)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35548.1 GenPept UniProtKB/Swiss-Prot:O35548

Gene LinkOut

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