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SLC2A3 solute carrier family 2 member 3 [ Homo sapiens (human) ]

Gene ID: 6515, updated on 11-Apr-2024

Summary

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Official Symbol
SLC2A3provided by HGNC
Official Full Name
solute carrier family 2 member 3provided by HGNC
Primary source
HGNC:HGNC:11007
See related
Ensembl:ENSG00000059804 MIM:138170; AllianceGenome:HGNC:11007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT3
Summary
Enables dehydroascorbic acid transmembrane transporter activity; glucose binding activity; and glucose transmembrane transporter activity. Involved in glucose import across plasma membrane and transport across blood-brain barrier. Is integral component of plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 183.0), placenta (RPKM 54.5) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
12p13.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7919230..7936187, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7933413..7950362, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8071826..8088783, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 14 Neighboring gene myosin light chain 9 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8025026-8025706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8033506-8034091 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8034092-8034676 Neighboring gene Sharpr-MPRA regulatory region 8483 Neighboring gene Nanog homeobox pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:8057929-8058458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8060583-8061114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8062177-8062706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8065488-8066477 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:8086891-8087844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4205 Neighboring gene CRISPRi-validated cis-regulatory element chr12.441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5923 Neighboring gene CRISPRi-validated cis-regulatory element chr12.444 Neighboring gene CRISPRi-validated cis-regulatory element chr12.445 Neighboring gene uncharacterized LOC124902871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8120522-8121234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8121235-8121947 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8123373-8124086 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:8134452-8135651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:8145332-8146221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8147335-8148256 Neighboring gene ribosomal protein S20 pseudogene 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evolutionary balance between foldability and functionality of a glucose transporter. Choi HK, et al. Nat Chem Biol, 2022 Jul. PMID 35484435, Free PMC Article
  2. SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population. Ma L, et al. J Clin Lab Anal, 2022 Jun. PMID 35466476, Free PMC Article
  3. Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Wu D, et al. Nat Metab, 2021 May. PMID 34031595, Free PMC Article
  4. Overexpression of GLUT3 promotes metastasis of triple-negative breast cancer by modulating the inflammatory tumor microenvironment. Tsai TH, et al. J Cell Physiol, 2021 Jun. PMID 33421130
  5. SLC2A3 rs12842 polymorphism and risk for Alzheimer's disease. Arseniou S, et al. Neurol Res, 2020 Oct. PMID 32627711

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
    Title: Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
  2. GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
    Title: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
  3. Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
    Title: Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
  4. The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
    Title: The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
  5. Evolutionary balance between foldability and functionality of a glucose transporter.
    Title: Evolutionary balance between foldability and functionality of a glucose transporter.
  6. SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population.
    Title: SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population.
  7. RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.
    Title: RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.
  8. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
    Title: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
  9. miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.
    Title: miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.
  10. Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
    Title: Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (109)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dehydroascorbic acid transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
NOT enables fructose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-ascorbic acid metabolic process TAS
Traceable Author Statement
more info
  
involved_in carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in dehydroascorbic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in fructose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transport across blood-brain barrier IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in aggresome IDA
Inferred from Direct Assay
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 3
Names
GLUT-3
glucose transporter type 3, brain
solute carrier family 2 (facilitated glucose transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006931.3 → NP_008862.1  solute carrier family 2, facilitated glucose transporter member 3

    See identical proteins and their annotated locations for NP_008862.1

    Status: VALIDATED

    Source sequence(s)
    AC007536
    Consensus CDS
    CCDS8586.1
    UniProtKB/Swiss-Prot
    B2R606, D3DUU6, P11169, Q6I9U2, Q9UG15
    UniProtKB/TrEMBL
    B7Z966
    Related
    ENSP00000075120.7, ENST00000075120.12
    Conserved Domains (1) summary
    cd17431
    Location:12 → 456
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7919230..7936187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7933413..7950362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11169.1 GenPept UniProtKB/Swiss-Prot:P11169

Gene LinkOut

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