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Adgrl1 adhesion G protein-coupled receptor L1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65096, updated on 2-May-2024

Summary

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Official Symbol
Adgrl1provided by RGD
Official Full Name
adhesion G protein-coupled receptor L1provided by RGD
Primary source
RGD:620768
See related
Ensembl:ENSRNOG00000029134 AllianceGenome:RGD:620768
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CL1BA; Lphn1
Summary
Enables cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and positive regulation of synapse maturation. Located in growth cone; postsynaptic density; and presynaptic membrane. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 198.5), Kidney (RPKM 133.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41107162..41148752, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24202405..24244137, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25029037..25069146)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene uncharacterized LOC120098559 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene uncharacterized LOC120098560 Neighboring gene uncharacterized LOC134483330 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134483629

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dissociation of the subunits of the calcium-independent receptor of alpha-latrotoxin as a result of two-step proteolysis. Krasnoperov V, et al. Biochemistry, 2009 Apr 14. PMID 19161337, Free PMC Article
  2. Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif. Krasnoperov V, et al. J Biol Chem, 2002 Nov 29. PMID 12270923
  3. Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion. A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants. Krasnoperov V, et al. J Biol Chem, 1999 Feb 5. PMID 9920906
  4. alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Krasnoperov VG, et al. Neuron, 1997 Jun. PMID 9208860
  5. Isolation and biochemical characterization of a Ca2+-independent alpha-latrotoxin-binding protein. Davletov BA, et al. J Biol Chem, 1996 Sep 20. PMID 8798521

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination.
    Title: Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination.
  2. Neurexin 1 binding to latrophilin-1 produces a stable intercellular adhesion complex.
    Title: High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex.
  3. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
    Title: Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
  4. further cleavage of CIRL by a second protease results in a soluble form of CIRL
    Title: Dissociation of the subunits of the calcium-independent receptor of alpha-latrotoxin as a result of two-step proteolysis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables cell adhesion molecule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables latrotoxin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables latrotoxin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables toxic substance binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor L1
Names
CIRL-1
calcium-independent alpha-latrotoxin receptor 1
latrophilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022962.1 → NP_075251.1  adhesion G protein-coupled receptor L1 precursor

    See identical proteins and their annotated locations for NP_075251.1

    Status: PROVISIONAL

    Source sequence(s)
    AF081146
    UniProtKB/TrEMBL
    A0A8I6AG63
    Related
    ENSRNOP00000089805.1, ENSRNOT00000101400.1
    Conserved Domains (7) summary
    smart00303
    Location:797 → 849
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476 → 539
    HormR; Domain present in hormone receptors
    pfam00002
    Location:857 → 1092
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1112 → 1471
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:550 → 771
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142 → 398
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    41107162..41148752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097967.2 → XP_038953895.1  adhesion G protein-coupled receptor L1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AG63, A6IYC5
    Related
    ENSRNOP00000086387.1
    Conserved Domains (8) summary
    smart00303
    Location:792 → 844
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 477
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:851 → 1108
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1107 → 1466
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 768
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  2. XM_039097965.2 → XP_038953893.1  adhesion G protein-coupled receptor L1 isoform X2

    UniProtKB/Swiss-Prot
    O09026, O35818, O88916, O88917
    UniProtKB/TrEMBL
    A6IYC6
    Conserved Domains (8) summary
    smart00303
    Location:792 → 844
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 477
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:851 → 1108
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1107 → 1511
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 768
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  3. XM_039097964.2 → XP_038953892.1  adhesion G protein-coupled receptor L1 isoform X1

    UniProtKB/Swiss-Prot
    O09026, O35818, O88916, O88917
    Conserved Domains (8) summary
    smart00303
    Location:797 → 849
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476 → 539
    HormR; Domain present in hormone receptors
    PHA03247
    Location:398 → 482
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:856 → 1113
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1112 → 1516
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:549 → 773
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142 → 398
    OLF; Olfactomedin-like domain

  4. XM_039097966.2 → XP_038953894.1  adhesion G protein-coupled receptor L1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AG63
    Conserved Domains (8) summary
    smart00303
    Location:798 → 850
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:477 → 540
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 483
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:857 → 1114
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1472
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:550 → 774
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  5. XM_039097969.2 → XP_038953897.1  adhesion G protein-coupled receptor L1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6G3M0
    Conserved Domains (7) summary
    smart00303
    Location:694 → 746
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:373 → 436
    HormR; Domain present in hormone receptors
    PHA03247
    Location:295 → 379
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:753 → 1010
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1009 → 1368
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:446 → 670
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:39 → 295
    OLF; Olfactomedin-like domain

  6. XM_039097968.2 → XP_038953896.1  adhesion G protein-coupled receptor L1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6G3M0
    Conserved Domains (7) summary
    smart00303
    Location:699 → 751
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:378 → 441
    HormR; Domain present in hormone receptors
    PHA03247
    Location:300 → 384
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:758 → 1015
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:1014 → 1373
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:451 → 675
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:44 → 300
    OLF; Olfactomedin-like domain

  7. XM_039097971.2 → XP_038953899.1  adhesion G protein-coupled receptor L1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AB35, A0A8I6G3M0, A6IYC7
    Conserved Domains (7) summary
    smart00303
    Location:621 → 673
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:300 → 363
    HormR; Domain present in hormone receptors
    PHA03247
    Location:222 → 306
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:680 → 937
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02354
    Location:936 → 1295
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:373 → 597
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:1 → 222
    OLF; Olfactomedin-like domain

  8. XM_063278273.1 → XP_063134343.1  adhesion G protein-coupled receptor L1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AB35, A6IYC7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88917.1 GenPept UniProtKB/Swiss-Prot:O88917

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