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SLC1A2 solute carrier family 1 member 2 [ Homo sapiens (human) ]

Gene ID: 6506, updated on 4-Jan-2025

Summary

Official Symbol
SLC1A2provided by HGNC
Official Full Name
solute carrier family 1 member 2provided by HGNC
Primary source
HGNC:HGNC:10940
See related
Ensembl:ENSG00000110436 MIM:600300; AllianceGenome:HGNC:10940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLT1; HBGT; DEE41; EAAT2; GLT-1; EIEE41
Summary
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]
Expression
Restricted expression toward brain (RPKM 153.3) See more
Orthologs
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Genomic context

See SLC1A2 in Genome Data Viewer
Location:
11p13
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (35251205..35420507, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (35389505..35559339, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (35272752..35441605, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4619 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35194606-35195107 Neighboring gene small nucleolar RNA, C/D box 164 Neighboring gene CD44 molecule (IN blood group) Neighboring gene NANOG hESC enhancer GRCh37_chr11:35227049-35227813 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:35235787-35236986 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35238494-35239323 Neighboring gene CD44 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4622 Neighboring gene SLC1A2 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35316953-35317454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4623 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:35351933-35352492 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35366234-35366761 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35369348-35369849 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35440751-35441251 Neighboring gene SLC1A2 antisense RNA 2 Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3259 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:35639867-35640028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640328-35640962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640963-35641597 Neighboring gene four-jointed box kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 41
MedGen: C4310717 OMIM: 617105 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
EBI GWAS Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog
Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Astrocyte elevated gene (AEG)-1 expression is increased in astrocytes infected with HIV-1 or treated with HIV-1 gp120; AEG-1 inhibits excitatory amino acid transporter 2 (EAAT2) promoter activity with the potential to promote glutamate excito-toxicity PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of solute carrier family 1, member 2 (SLC1A2; glial high affinity glutamate transporter) in immature dendritic cells and PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 28
Process Evidence Code Pubs
involved_in D-aspartate import across plasma membrane PubMed 
involved_in L-aspartate import across plasma membrane PubMed 
involved_in L-aspartate transmembrane transport  
involved_in L-aspartate transmembrane transport  
involved_in L-glutamate import across plasma membrane  
involved_in L-glutamate import across plasma membrane PubMed 
involved_in L-glutamate import across plasma membrane PubMed 
involved_in L-glutamate transmembrane transport PubMed 
involved_in adult behavior  
involved_in cellular response to cocaine  
involved_in chemical synaptic transmission PubMed 
involved_in cysteine transmembrane transport  
involved_in glutathione biosynthetic process  
involved_in monoatomic anion transmembrane transport  
involved_in monoatomic ion transport  
involved_in multicellular organism growth  
involved_in neurotransmitter reuptake  
involved_in neurotransmitter transport  
involved_in positive regulation of D-glucose import  
involved_in protein homotrimerization PubMed 
involved_in response to amino acid  
involved_in response to wounding  
involved_in response to xenobiotic stimulus  
involved_in telencephalon development  
involved_in transepithelial transport  
involved_in transport across blood-brain barrier  
involved_in transport across blood-brain barrier PubMed 
involved_in visual behavior  
Items 1 - 25 of 28
Component Evidence Code Pubs
located_in astrocyte projection  
located_in axolemma  
located_in cell body  
located_in cell surface PubMed 
located_in glutamatergic synapse  
located_in membrane PubMed 
part_of membrane protein complex PubMed 
part_of membrane protein complex  
located_in membrane raft PubMed 
located_in membrane raft PubMed 
located_in neuron projection terminus  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in presynaptic membrane PubMed 
located_in vesicle  

General protein information

Preferred Names
excitatory amino acid transporter 2
Names
excitotoxic amino acid transporter 2
glutamate transporter-1
glutamate/aspartate transporter II
human brain glutamate transporter
sodium-dependent glutamate/aspartate transporter 2
solute carrier family 1 (glial high affinity glutamate transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008727.2 RefSeqGene

    Range
    5001..173354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195728.3NP_001182657.1  excitatory amino acid transporter 2 isoform 2

    See identical proteins and their annotated locations for NP_001182657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    BC047052, BC132768, BX538155, DA215039, U01824
    Consensus CDS
    CCDS55756.1
    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
    Related
    ENSP00000494025.1, ENST00000647104.1
    Conserved Domains (1) summary
    pfam00375
    Location:37487
    SDF; Sodium:dicarboxylate symporter family
  2. NM_001252652.2NP_001239581.1  excitatory amino acid transporter 2 isoform 2

    See identical proteins and their annotated locations for NP_001239581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AC090625, AK122843, BC047052, BC132768, BX538155
    Consensus CDS
    CCDS55756.1
    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
    Related
    ENSP00000493945.1, ENST00000645634.1
    Conserved Domains (1) summary
    pfam00375
    Location:37487
    SDF; Sodium:dicarboxylate symporter family
  3. NM_004171.4NP_004162.2  excitatory amino acid transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_004162.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL133330, BC047052, D85884, DA158200, DB465494
    Consensus CDS
    CCDS31459.1
    UniProtKB/Swiss-Prot
    B4DQE9, P43004, Q14417, Q541G6, U3KQQ4
    UniProtKB/TrEMBL
    Q59FL6
    Related
    ENSP00000278379.3, ENST00000278379.9
    Conserved Domains (1) summary
    pfam00375
    Location:46496
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    35251205..35420507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427443.1XP_047283399.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  2. XM_011520285.2XP_011518587.1  excitatory amino acid transporter 2 isoform X4

    See identical proteins and their annotated locations for XP_011518587.1

    UniProtKB/TrEMBL
    A0A2U3TZS7, Q59FL6
    Related
    ENSP00000379099.2, ENST00000395750.6
    Conserved Domains (1) summary
    pfam00375
    Location:42492
    SDF; Sodium:dicarboxylate symporter family
  3. XM_017018138.2XP_016873627.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
    Related
    ENSP00000495164.1, ENST00000643000.1
    Conserved Domains (1) summary
    pfam00375
    Location:37487
    SDF; Sodium:dicarboxylate symporter family
  4. XM_017018137.2XP_016873626.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
    Related
    ENSP00000379102.1, ENST00000395753.6
    Conserved Domains (1) summary
    pfam00375
    Location:37487
    SDF; Sodium:dicarboxylate symporter family
  5. XM_017018139.2XP_016873628.1  excitatory amino acid transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A2R8YFE3, Q59FL6
    Related
    ENSP00000496375.1, ENST00000643522.1
  6. XM_047427442.1XP_047283398.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  7. XM_047427440.1XP_047283396.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
    Related
    ENSP00000494669.1, ENST00000644299.1
  8. XM_047427437.1XP_047283393.1  excitatory amino acid transporter 2 isoform X2

    UniProtKB/TrEMBL
    Q59FL6
  9. XM_047427438.1XP_047283394.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  10. XM_017018136.1XP_016873625.1  excitatory amino acid transporter 2 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Y860, Q59FL6
    Related
    ENSP00000496667.1, ENST00000645303.1
  11. XM_047427441.1XP_047283397.1  excitatory amino acid transporter 2 isoform X7

    UniProtKB/TrEMBL
    Q59FL6
  12. XM_047427436.1XP_047283392.1  excitatory amino acid transporter 2 isoform X1

    UniProtKB/TrEMBL
    Q59FL6
    Related
    ENSP00000495126.1, ENST00000643454.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    35389505..35559339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369680.1XP_054225655.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  2. XM_054369673.1XP_054225648.1  excitatory amino acid transporter 2 isoform X4

    UniProtKB/TrEMBL
    A0A2U3TZS7, Q59FL6
  3. XM_054369676.1XP_054225651.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  4. XM_054369675.1XP_054225650.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  5. XM_054369678.1XP_054225653.1  excitatory amino acid transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A2R8YFE3, Q59FL6
  6. XM_054369679.1XP_054225654.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  7. XM_054369677.1XP_054225652.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  8. XM_054369671.1XP_054225646.1  excitatory amino acid transporter 2 isoform X2

    UniProtKB/TrEMBL
    Q59FL6
  9. XM_054369674.1XP_054225649.1  excitatory amino acid transporter 2 isoform X5

    UniProtKB/TrEMBL
    A2A2U1, Q59FL6
  10. XM_054369672.1XP_054225647.1  excitatory amino acid transporter 2 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Y860, Q59FL6
  11. XM_054369670.1XP_054225645.1  excitatory amino acid transporter 2 isoform X1

    UniProtKB/TrEMBL
    Q59FL6
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