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Serpina5 serpin family A member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65051, updated on 5-Mar-2024

Summary

Official Symbol
Serpina5provided by RGD
Official Full Name
serpin family A member 5provided by RGD
Primary source
RGD:619817
See related
Ensembl:ENSRNOG00000009855 AllianceGenome:RGD:619817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pci
Summary
Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis and seminal vesicle development. Predicted to be located in several cellular components, including extracellular exosome; platelet dense tubular network; and secretory granule. Predicted to be part of several cellular components, including protein C inhibitor-KLK3 complex; protein C inhibitor-PLAT complex; and protein C inhibitor-PLAU complex. Predicted to be active in extracellular space. Orthologous to human SERPINA5 (serpin family A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 127.8) and Liver (RPKM 71.9) See more
Orthologs
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Genomic context

Location:
6q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128774006..128793187)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (123009224..123028412)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127753152..127772403)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351294 Neighboring gene serpin family A member 12 Neighboring gene serpin family A member 4 Neighboring gene serpin family A member 3M Neighboring gene importin 11, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC93420

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acrosin binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in seminal vesicle development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
located_in platelet dense tubular network ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-KLK3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-PLAT complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-PLAU complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-TMPRSS11E complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-TMPRSS7 complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-coagulation factor V complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-coagulation factor XI complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-coagulation factor Xa complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-plasma kallikrein complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein C inhibitor-thrombin complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plasma serine protease inhibitor
Names
protein C inhibitor
serine (or cysteine) peptidase inhibitor, clade A, member 5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
serpin peptidase inhibitor, clade A, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244739.1NP_001231668.1  plasma serine protease inhibitor isoform 1

    See identical proteins and their annotated locations for NP_001231668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    BC081797, CK603584
    UniProtKB/TrEMBL
    A6JEQ3, Q66HL5
    Conserved Domains (1) summary
    cd02056
    Location:81439
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  2. NM_022957.3NP_075246.3  plasma serine protease inhibitor isoform 2 precursor

    See identical proteins and their annotated locations for NP_075246.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice junction in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BC097315, CK603584
    UniProtKB/TrEMBL
    F7EMJ6, Q66HL5
    Related
    ENSRNOP00000013138.5, ENSRNOT00000013138.7
    Conserved Domains (1) summary
    cl38926
    Location:47410
    serpin; SERine Proteinase INhibitors (serpin) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    128774006..128793187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240494.5XP_006240556.1  plasma serine protease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006240556.1

    UniProtKB/TrEMBL
    F7EMJ6, Q66HL5
    Conserved Domains (1) summary
    cl38926
    Location:47410
    serpin; SERine Proteinase INhibitors (serpin) family
  2. XM_017594349.3XP_017449838.1  plasma serine protease inhibitor isoform X1

    UniProtKB/TrEMBL
    F7EMJ6, Q66HL5
    Conserved Domains (1) summary
    cl38926
    Location:47410
    serpin; SERine Proteinase INhibitors (serpin) family
  3. XM_039112916.2XP_038968844.1  plasma serine protease inhibitor isoform X1

    UniProtKB/TrEMBL
    F7EMJ6, Q66HL5
    Conserved Domains (1) summary
    cl38926
    Location:47410
    serpin; SERine Proteinase INhibitors (serpin) family