Bche butyrylcholinesterase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcheprovided by RGD
Official Full Name: butyrylcholinesteraseprovided by RGD
Primary source: RGD:619996
See related: Ensembl:ENSRNOG00000009826 AllianceGenome:RGD:619996
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables choline binding activity and cholinesterase activity. Involved in several processes, including neuroblast differentiation; response to folic acid; and response to glucocorticoid. Located in endoplasmic reticulum lumen; extracellular space; and membrane. Used to study amnestic disorder and hyperhomocysteinemia. Biomarker of leptospirosis and trypanosomiasis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 176.5), Liver (RPKM 64.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (160607289..160699760, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (158308674..158401148, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (171104476..171196186, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aortic butyrylcholinesterase is reduced in spontaneously hypertensive rats.
Title: Aortic butyrylcholinesterase is reduced in spontaneously hypertensive rats.
No significant difference was observed in the activity of BChE in serum after Toxoplasma gondii infection.
Title: Influence of Toxoplasma gondii acute infection on cholinesterase activities of Wistar rats.
the absence of any effects on BuChE activity implies that growth hormone does not affect the development of non-neuronal elements
Title: Postnatal growth hormone deficiency in growing rats causes marked decline in the activity of spinal cord acetylcholinesterase but not butyrylcholinesterase.
the neurochemical development of glia and other non-neuronal cells, where BuChE is mainly localized, is comparatively unaffected cy hypo- and hyperthyroidism
Title: Differential effects of developmental hypo- and hyperthyroidism on acetylcholinesterase and butyrylcholinesterase activity in the spinal cord of developing postnatal rat pups.
Report differential cholinesterase inhibition in the rat brain regions by dichlorvos and protective effect of Decalepis hamiltonii root antioxidants.
Title: Differential cholinesterase inhibition in the rat brain regions by dichlorvos and protective effect of Decalepis hamiltonii roots.
BChE knock down resulted in an up-regulation of not only acetylcholinesterase (AChE), but also altered the signaling status of PKC and ERK.
Title: Counter-regulation of cholinesterases: differential activation of PKC and ERK signaling in retinal cells through BChE knockdown.
Results showed that arginine in vitro significantly decreased acetylcholinesterase activity in hippocampus of 15-day-old rats.
Title: Guanidino compounds inhibit acetylcholinesterase and butyrylcholinesterase activities: effect neuroprotector of vitamins E plus C.
Liver and plasma butyrylcholinesterase, but not acetylcholinesterase, expression is influenced by sex hormones.
Title: Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: effects of sex hormone withdrawal.
The hydrolytic rate of BCH12 and longer alkyl chain esters vs. substrate concentration showed a premature plateau far below V(max). The best substrates for rat butyrylcholinesterase were short alkyl homologues, BzCh - BCH4.
Title: Rat butyrylcholinesterase-catalysed hydrolysis of N-alkyl homologues of benzoylcholine.
The data suggest that the inhibitory effect of Homocysteine on BuChE activity is probably mediated by free radicals, since vitamins E and C administration prevented such effect.
Title: Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholinesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholinesterase activity	ISO Inferred from Sequence Orthology more info
enables choline binding	IDA Inferred from Direct Assay more info	PubMed
enables cholinesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables cholinesterase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in choline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in choline metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in learning	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to alkaloid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to folic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cholinesterase

NP_075231.1

EC 3.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022942.1 → NP_075231.1 cholinesterase precursor

See identical proteins and their annotated locations for NP_075231.1

Status: PROVISIONAL

Source sequence(s)

AF244349

UniProtKB/TrEMBL

A0A8J8XQI9, F1LQK0, Q9JKC1

Related

ENSRNOP00000013279.3, ENSRNOT00000013279.4

Conserved Domains (3) summary

COG0657
Location:120 → 272

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:21 → 545

COesterase; Carboxylesterase family

pfam08674
Location:560 → 594

AChE_tetra; Acetylcholinesterase tetramerization domain