Aoc1 amine oxidase, copper containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aoc1provided by RGD
Official Full Name: amine oxidase, copper containing 1provided by RGD
Primary source: RGD:61296
See related: Ensembl:ENSRNOG00000008575 AllianceGenome:RGD:61296
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abp; Abp1
Summary: Enables diamine oxidase activity and organic cyclic compound binding activity. Involved in cellular response to copper ion starvation and response to antibiotic. Acts upstream of or within amiloride transport. Located in bicellular tight junction. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 56.6), Lung (RPKM 27.1) and 2 other tissues See more
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Genomic context

Location:: 4q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (79143126..79162705)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (77812260..77831846)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (78496043..78515582)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAO secretion may contribute to the catabolism of histamine released during fat absorption and this is probably mediated through the histamine H(4) receptor.
Title: Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release.
Measurement of serum diamine oxidase levels might provide a marker for early diagnosis of superior mesenteric arterial occlusion.
Title: Diamine oxidase as a marker for diagnosis of superior mesenteric arterial occlusion.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128193 (e-PCR)
- UniSTS:211501

RH129281 (e-PCR)
- UniSTS:212588

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables diamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables diamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables histamine oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methylputrescine oxidase activity	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables primary amine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables primary amine oxidase activity	IEA Inferred from Electronic Annotation more info
enables primary amine oxidase activity	ISO Inferred from Sequence Orthology more info
enables propane-1,3-diamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables putrescine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables putrescine oxidase activity	ISO Inferred from Sequence Orthology more info
enables putrescine oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in putrescine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in putrescine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to antibiotic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: diamine oxidase [copper-containing]; amiloride-sensitive amine oxidase [copper-containing]

Names: DAO; amiloride binding protein 1 (amine oxidase, copper-containing); amiloride-binding protein 1; amiloride-sensitive amine oxidase; amine oxidase copper domain-containing protein 1; diamine oxidase; histaminase

NP_075224.2

EC 1.4.3.22

XP_006236533.1

EC 1.4.3.22

XP_063142738.1

EC 1.4.3.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022935.2 → NP_075224.2 diamine oxidase [copper-containing] precursor

See identical proteins and their annotated locations for NP_075224.2

Status: PROVISIONAL

Source sequence(s)

BC100144

UniProtKB/Swiss-Prot

P36633, Q63973

UniProtKB/TrEMBL

F6WEU8, Q498N2

Related

ENSRNOP00000055909.1, ENSRNOT00000059136.3

Conserved Domains (3) summary

pfam01179
Location:301 → 712

Cu_amine_oxid; Copper amine oxidase, enzyme domain

pfam02727
Location:44 → 130

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 246

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

79143126..79162705

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286668.1 → XP_063142738.1 amiloride-sensitive amine oxidase [copper-containing] isoform X1

UniProtKB/TrEMBL

F6WEU8, Q498N2
XM_006236471.5 → XP_006236533.1 amiloride-sensitive amine oxidase [copper-containing] isoform X1

See identical proteins and their annotated locations for XP_006236533.1

UniProtKB/Swiss-Prot

P36633, Q63973

UniProtKB/TrEMBL

F6WEU8, Q498N2

Conserved Domains (3) summary

pfam01179
Location:301 → 712

Cu_amine_oxid; Copper amine oxidase, enzyme domain

pfam02727
Location:44 → 130

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:146 → 246

Cu_amine_oxidN3; Copper amine oxidase, N3 domain