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Phka1 phosphorylase kinase regulatory subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64561, updated on 3-Apr-2024

Summary

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Official Symbol
Phka1provided by RGD
Official Full Name
phosphorylase kinase regulatory subunit alpha 1provided by RGD
Primary source
RGD:621522
See related
Ensembl:ENSRNOG00000003063 AllianceGenome:RGD:621522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcyt1b
Summary
Predicted to enable choline-phosphate cytidylyltransferase activity. Involved in protein autophosphorylation. Part of phosphorylase kinase complex. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease IXd. Orthologous to human PHKA1 (phosphorylase kinase regulatory subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1002.7), Heart (RPKM 88.4) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq22
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (71639701..71778465, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (67601302..67738504, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (72377020..72515385, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Neighboring gene histone deacetylase 8 Neighboring gene ribosomal protein S27a, pseudogene 3 Neighboring gene kelch domain containing 2 like 1 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 16 Neighboring gene DMRT-like family C1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Baculovirus-mediated overexpression of the phosphorylase b kinase holoenzyme and alpha gamma delta and gamma delta subcomplexes. Kumar P, et al. Biochemistry, 2004 Aug 10. PMID 15287752
  2. Phosphorylase a formation in protein-glycogen particles isolated from fast-twitch muscle of euthyroid and hypothyroid rats. Leijendekker WJ, et al. Arch Biochem Biophys, 1989 Oct. PMID 2774570
  3. Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranes. Johnson JE, et al. J Biol Chem, 2003 Jan 3. PMID 12401806
  4. The content of glycogen phosphorylase and glycogen in preparations of sarcoplasmic reticulum-glycogenolytic complex is enhanced in diabetic rat skeletal muscle. Garduño E, et al. Diabetologia, 2001 Oct. PMID 11692172
  5. cDNA cloning and complete primary structure of skeletal muscle phosphorylase kinase (alpha subunit). Zander NF, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 3362857, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables choline-phosphate cytidylyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphorylase kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphorylase kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
Names
PhK-alpha-subunit
phosphorylase B kinase alpha subunit
phosphorylase kinase alpha M subunit
phosphorylase kinase alpha-subunit
phosphorylase kinase, alpha 1
NP_072148.2
XP_006257164.1
XP_063136353.1
XP_063136354.1
XP_063136355.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022626.2 → NP_072148.2  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q64649, Q64650, Q64651, Q9QZ77
    UniProtKB/TrEMBL
    A0A096MJF7
    Related
    ENSRNOP00000068112.1, ENSRNOT00000076850.3
    Conserved Domains (3) summary
    pfam00723
    Location:8 → 439
    Glyco_hydro_15; Glycosyl hydrolases family 15
    pfam19292
    Location:1078 → 1152
    KPBB_C; Phosphorylase b kinase C-terminal domain
    cl42434
    Location:806 → 923
    Glyco_hydro_15; Glycosyl hydrolases family 15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    71639701..71778465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257102.5 → XP_006257164.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X3

    UniProtKB/Swiss-Prot
    Q64649, Q64650, Q64651, Q9QZ77
    UniProtKB/TrEMBL
    A0A096MJV9
    Related
    ENSRNOP00000068281.1
    Conserved Domains (1) summary
    pfam00723
    Location:8 → 439
    Glyco_hydro_15; Glycosyl hydrolases family 15

  2. XM_063280283.1 → XP_063136353.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1

    UniProtKB/TrEMBL
    A0A8I6A560

  3. XM_063280285.1 → XP_063136355.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X4

  4. XM_063280284.1 → XP_063136354.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64649.2 GenPept UniProtKB/Swiss-Prot:Q64649

Gene LinkOut

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