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Tkt transketolase [ Rattus norvegicus (Norway rat) ]

Gene ID: 64524, updated on 13-Apr-2024

Summary

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Official Symbol
Tktprovided by RGD
Official Full Name
transketolaseprovided by RGD
Primary source
RGD:621036
See related
Ensembl:ENSRNOG00000016064 AllianceGenome:RGD:621036
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cation binding activity; monosaccharide binding activity; and transketolase activity. Involved in pentose-phosphate shunt, non-oxidative branch and ribose phosphate biosynthetic process. Located in endoplasmic reticulum membrane and peroxisome. Orthologous to human TKT (transketolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 1900.0), Thymus (RPKM 1783.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (5729381..5755170)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (5723764..5748702)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (6609670..6634608)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene uncharacterized LOC120097386 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene decapping mRNA 1A Neighboring gene uncharacterized LOC134482445 Neighboring gene protein kinase C, delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Downregulation of transketolase activity is related to inhibition of hippocampal progenitor cell proliferation induced by thiamine deficiency. Zhao Y, et al. Biomed Res Int, 2014. PMID 25028661, Free PMC Article
  2. In situ localization of transketolase activity in epithelial cells of different rat tissues and subcellularly in liver parenchymal cells. Boren J, et al. J Histochem Cytochem, 2006 Feb. PMID 16116031
  3. The crystal structure of human transketolase and new insights into its mode of action. Mitschke L, et al. J Biol Chem, 2010 Oct 8. PMID 20667822, Free PMC Article
  4. Transketolase haploinsufficiency reduces adipose tissue and female fertility in mice. Xu ZP, et al. Mol Cell Biol, 2002 Sep. PMID 12167708, Free PMC Article
  5. Heterologous expression of human transketolase. Schenk G, et al. Int J Biochem Cell Biol, 1998 Mar. PMID 9611778

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that modulation of transketolase activity might be one of the mechanisms by which thiamine regulates the proliferation of hippocampal progenitor cells.
    Title: Downregulation of transketolase activity is related to inhibition of hippocampal progenitor cell proliferation induced by thiamine deficiency.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables monosaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine pyrophosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transketolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transketolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transketolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glyceraldehyde-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of growth ISO
Inferred from Sequence Orthology
more info
  
involved_in xylulose 5-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xylulose 5-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transketolase
Names
TK
NP_072114.2
XP_006252723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022592.2 → NP_072114.2  transketolase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6KG34, G3V826
    Related
    ENSRNOP00000021862.4, ENSRNOT00000021862.7
    Conserved Domains (1) summary
    PRK05899
    Location:40 → 652
    PRK05899; transketolase; Reviewed

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    5729381..5755170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252661.2 → XP_006252723.1  transketolase isoform X1

    See identical proteins and their annotated locations for XP_006252723.1

    UniProtKB/Swiss-Prot
    P50137
    UniProtKB/TrEMBL
    A6KG36
    Related
    ENSRNOP00000095976.1
    Conserved Domains (1) summary
    PRK05899
    Location:8 → 620
    PRK05899; transketolase; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50137.1 GenPept UniProtKB/Swiss-Prot:P50137

Gene LinkOut

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