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Eif2b1 eukaryotic translation initiation factor 2B subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 64514, updated on 3-Apr-2024

Summary

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Official Symbol
Eif2b1provided by RGD
Official Full Name
eukaryotic translation initiation factor 2B subunit alphaprovided by RGD
Primary source
RGD:620819
See related
Ensembl:ENSRNOG00000001039 AllianceGenome:RGD:620819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
eIF-2a
Summary
Enables GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; response to amino acid starvation; and translational initiation. Part of eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 129.1), Adrenal (RPKM 104.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif2b1 in Genome Data Viewer
Location:
12q15
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37686149..37694830)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32025593..32033848)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37444136..37452391)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene tectonic family member 2 Neighboring gene transfer RNA alanine (anticodon AGC) 44 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 1 Neighboring gene general transcription factor IIH subunit 3 Neighboring gene DEAD-box helicase 55 Neighboring gene transmembrane p24 trafficking protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver. Kimball SR, et al. J Biol Chem, 1987 Feb 15. PMID 3818593
  2. Increased activity of eukaryotic initiation factor 2B in PC12 cells in response to differentiation by nerve growth factor. Muñoz F, et al. J Neurochem, 1998 Nov. PMID 9798914
  3. Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B. Flowers KM, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753796, Free PMC Article
  4. Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B. Flowers KM, et al. Biochim Biophys Acta, 1995 Nov 7. PMID 7495858
  5. Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Hussain SG, et al. Biochem Biophys Res Commun, 2007 Apr 6. PMID 17300747

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to amino acid starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to glucose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to peptide hormone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2B complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 2B complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
translation initiation factor eIF2B subunit alpha
Names
GTP-exchange protein
eIF-2B GDP-GTP exchange factor subunit alpha
eIF-2Balpha
eIF2B GDP-GTP exchange factor subunit alpha
eukaryotic translation initiation factor 2B subunit 1 alpha
translation initiation factor eIF-2B subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172029.2 → NP_742026.1  translation initiation factor eIF2B subunit alpha

    See identical proteins and their annotated locations for NP_742026.1

    Status: VALIDATED

    Source sequence(s)
    BC081709
    UniProtKB/Swiss-Prot
    Q64270
    UniProtKB/TrEMBL
    A0A0G2JV57, A6J0Y3
    Related
    ENSRNOP00000075870.1, ENSRNOT00000092416.2
    Conserved Domains (2) summary
    COG1184
    Location:5 → 305
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:17 → 293
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    37686149..37694830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271616.1 → XP_063127686.1  translation initiation factor eIF2B subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A0U1RRZ2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64270.1 GenPept UniProtKB/Swiss-Prot:Q64270

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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