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Adcy3 adenylate cyclase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64508, updated on 4-Jan-2025

Summary

Official Symbol
Adcy3provided by RGD
Official Full Name
adenylate cyclase 3provided by RGD
Primary source
RGD:71009
See related
EnsemblRapid:ENSRNOG00000003999 AllianceGenome:RGD:71009
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process and cellular response to forskolin. Located in several cellular components, including apical cytoplasm; dendritic knob; and sperm midpiece. Part of ciliary necklace. Biomarker of cardiomyopathy and diabetes mellitus. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 78.1), Thymus (RPKM 49.3) and 9 other tissues See more
Orthologs
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Genomic context

See Adcy3 in Genome Data Viewer
Location:
6q14
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (32819602..32923174)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27100089..27203686)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (28570941..28648848)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103495 Neighboring gene EFR3 homolog B Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene general transcription factor IIH subunit 5-like Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 3 Neighboring gene centromere protein O Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene nuclear receptor coactivator 1 Neighboring gene transfer RNA serine (anticodon AGA) 24

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables adenylate cyclase activity  
enables adenylate cyclase activity PubMed 
enables adenylate cyclase activity  
enables adenylate cyclase activity  
enables adenylate cyclase activity  
enables calcium- and calmodulin-responsive adenylate cyclase activity PubMed 
enables calmodulin binding  
enables metal ion binding  
Items 1 - 25 of 26
Process Evidence Code Pubs
involved_in acrosome reaction  
involved_in acrosome reaction  
involved_in acrosome reaction  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in cAMP biosynthetic process  
involved_in cAMP biosynthetic process PubMed 
involved_in cAMP biosynthetic process  
involved_in cAMP biosynthetic process  
involved_in cellular response to forskolin PubMed 
involved_in cellular response to forskolin  
involved_in cellular response to forskolin  
involved_in flagellated sperm motility  
involved_in flagellated sperm motility  
involved_in flagellated sperm motility  
involved_in intracellular signal transduction  
involved_in olfactory learning  
involved_in olfactory learning  
involved_in olfactory learning  
involved_in sensory perception of smell  
acts_upstream_of_or_within sensory perception of smell  
involved_in sensory perception of smell  
involved_in single fertilization  
involved_in single fertilization  
Items 1 - 25 of 26
Items 1 - 20 of 22
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in acrosomal vesicle PubMed 
located_in apical cytoplasm PubMed 
located_in ciliary membrane  
located_in ciliary membrane  
part_of ciliary necklace PubMed 
located_in cilium PubMed 
located_in cilium  
located_in cilium  
located_in cytoplasm  
located_in cytoplasm  
located_in dendritic knob PubMed 
located_in membrane  
located_in membrane  
located_in neuronal cell body PubMed 
located_in nucleus PubMed 
located_in perinuclear region of cytoplasm PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in sperm midpiece PubMed 
Items 1 - 20 of 22

General protein information

Preferred Names
adenylate cyclase type 3
Names
AC-III
AC3
ATP pyrophosphate-lyase 3
adenylate cyclase type III
adenylate cyclase, olfactive type
adenylyl cyclase 3
type III adenylyl cyclase
NP_570135.2
XP_006239909.1
XP_006239910.1
XP_006239911.1
XP_006239912.1
XP_038968804.1
XP_063118515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130779.2NP_570135.2  adenylate cyclase type 3

    See identical proteins and their annotated locations for NP_570135.2

    Status: PROVISIONAL

    Source sequence(s)
    AW525494, CB720821, M55075
    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:9141121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    32819602..32923174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112876.2XP_038968804.1  adenylate cyclase type 3 isoform X1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:9141121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  2. XM_006239847.5XP_006239909.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006239909.1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:9141121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  3. XM_063262445.1XP_063118515.1  adenylate cyclase type 3 isoform X2

    UniProtKB/Swiss-Prot
    P21932
  4. XM_006239848.5XP_006239910.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006239910.1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:9141121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  5. XM_006239849.5XP_006239911.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006239911.1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Related
    ENSRNOP00000005389.4, ENSRNOT00000005389.8
    Conserved Domains (2) summary
    pfam00211
    Location:9141121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  6. XM_006239850.5XP_006239912.1  adenylate cyclase type 3 isoform X2

    UniProtKB/Swiss-Prot
    P21932
    Conserved Domains (3) summary
    smart00044
    Location:8821100
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:9131120
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
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