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Masp2 MBL associated serine protease 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64459, updated on 11-Apr-2024

Summary

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Official Symbol
Masp2provided by RGD
Official Full Name
MBL associated serine protease 2provided by RGD
Primary source
RGD:620214
See related
Ensembl:ENSRNOG00000011258 AllianceGenome:RGD:620214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MAp19; MASP-2
Summary
Enables serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway. Predicted to be active in extracellular space. Orthologous to human MASP2 (MBL associated serine protease 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 632.8), Kidney (RPKM 47.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (164319017..164332686)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (159035892..159049561)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (165415105..165429857)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene exosome component 10 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein Neighboring gene small nucleolar RNA, H/ACA box 21 Neighboring gene similar to human chromosome 1 open reading frame 127 Neighboring gene ribosomal protein L14, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. Feinberg H, et al. EMBO J, 2003 May 15. PMID 12743029, Free PMC Article
  2. Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation. Nan R, et al. Structure, 2017 Feb 7. PMID 28111019, Free PMC Article
  3. Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins. Girija UV, et al. J Immunol, 2007 Jul 1. PMID 17579066, Free PMC Article
  4. Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency. Wallis R, et al. J Immunol, 2005 Nov 15. PMID 16272342
  5. The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement. Stover CM, et al. J Immunol, 1999 Dec 15. PMID 10586086

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flexibility in MASP-1 and MASP-2 provides insight on lectin pathway activation.
    Title: Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
  2. MASP-1 probably enhances complement activation triggered by MBP.MASP-2 complexes, but it cannot initiate activation itself
    Title: Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.
  3. crystal structure of the MASP-2 CUB1-EGF-CUB2 dimer reveals an elongated structure with a prominent concave surface that is proposed to be the mannose-binding protein-binding site
    Title: Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2.
  4. A lysine residue (Lys56) within the conserved motif is essential for MASP-2 binding and probably mediates the specificity of the ficolin-MASP interaction.
    Title: Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins.
  5. Highly conserved intron sequences. Restricted expression contrasts with the ubiquitous expression of neighboring genes.
    Title: Organization of the MASP2 locus and its expression profile in mouse and rat.
  6. Analysis of mutant MBL . MASP-2 complexes assembled from recombinant components shows that reduced complement activation by mutant MBLs is caused by failure to activate MASP-2 efficiently on binding to a mannan-coated surface.
    Title: Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency.
  7. MASP-2, C4, and C2 and their activation fragments have roles in complement activation via the lectin pathway
    Title: Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables complement component C4b binding IEA
Inferred from Electronic Annotation
more info
  
enables complement component C4b binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in complement activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in complement activation, lectin pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in complement activation, lectin pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mannan-binding lectin serine protease 2
Names
mannan-binding lectin serine peptidase 2
mannose binding lectin-associated serine protease-2
mannose-binding protein-associated serine protease 2
NP_742040.1
XP_006239462.1
XP_006239463.1
XP_063144421.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172043.1 → NP_742040.1  mannan-binding lectin serine protease 2 precursor

    See identical proteins and their annotated locations for NP_742040.1

    Status: VALIDATED

    Source sequence(s)
    AJ277747, CO557085
    UniProtKB/Swiss-Prot
    Q9JJP3, Q9JJS8, Q9QX83, Q9QX84, Q9QX85, Q9QX86, Q9QX87, Q9QX88, Q9QX89, Q9QX90, Q9QX91, Q9QXD4, Q9WUZ0
    UniProtKB/TrEMBL
    A2VCV7, F7FHD3
    Related
    ENSRNOP00000016317.4, ENSRNOT00000016317.7
    Conserved Domains (5) summary
    smart00020
    Location:443 → 678
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:184 → 295
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:444 → 681
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:300 → 361
    Sushi; Sushi repeat (SCR repeat)
    pfam14670
    Location:152 → 180
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    164319017..164332686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288351.1 → XP_063144421.1  mannan-binding lectin serine protease 2 isoform X1

  2. XM_006239400.5 → XP_006239462.1  mannan-binding lectin serine protease 2 isoform X2

    Conserved Domains (2) summary
    cd00041
    Location:184 → 295
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam14670
    Location:152 → 180
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_006239401.4 → XP_006239463.1  mannan-binding lectin serine protease 2 isoform X3

    See identical proteins and their annotated locations for XP_006239463.1

    UniProtKB/TrEMBL
    A0A0G2K392, A6IU76
    Related
    ENSRNOP00000072546.2
    Conserved Domains (2) summary
    cd00041
    Location:19 → 136
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam14670
    Location:152 → 180
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJS8.2 GenPept UniProtKB/Swiss-Prot:Q9JJS8

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