Gpr88 G-protein coupled receptor 88 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr88provided by RGD
Official Full Name: G-protein coupled receptor 88provided by RGD
Primary source: RGD:61921
See related: Ensembl:ENSRNOG00000026953 AllianceGenome:RGD:61921
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled photoreceptor activity and cytoskeletal motor activity. Predicted to be involved in several processes, including cellular response to light stimulus; motor learning; and phototransduction. Predicted to act upstream of or within locomotory behavior; neuromuscular process controlling balance; and neuronal action potential. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human GPR88 (G protein-coupled receptor 88). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 104.7), Spleen (RPKM 91.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (206876373..206885034, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (204191443..204199576, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (219258346..219263819, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.
Title: G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.
Therefore, we conclude that GPR88 and GPR124 receptors may be involved in the development or maintenance of high blood pressure.
Title: Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat.
In the developing cortex, GPR88 shifts on the day of birth to the nuclei of neurons in layers V to II.
Title: Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.
Results suggest a role for Gpr88 in the regulation of cognitive and motor functions, and support its relevance to the pathophysiology and treatment of schizophrenia and other disorders involving dysfunction of the accumbens-striatal complex
Title: Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
GPR88 is confined to striatal medium spiny neurons and indicate that L-DOPA-mediated behavioural effects in hemiparkinsonian rats may involve normalization of striatal GPR88 levels
Title: Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents.

Submit: New GeneRIF Correction

General gene information

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Markers

Gpr88 (e-PCR), detects polymorphism
- UniSTS:506949

RH143430 (e-PCR)
- UniSTS:232677

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables beta2-adrenergic receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of visible light	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in motor learning	ISO Inferred from Sequence Orthology more info
involved_in motor learning	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G protein-coupled receptor 88

Names: probable G-protein coupled receptor 88; striatum-specific G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031696.2 → NP_113884.1 G protein-coupled receptor 88

See identical proteins and their annotated locations for NP_113884.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

206876373..206885034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103063.2 → XP_038958991.1 G protein-coupled receptor 88 isoform X1

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Related

ENSRNOP00000038233.2

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039103064.2 → XP_038958992.1 G protein-coupled receptor 88 isoform X1

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039103062.2 → XP_038958990.1 G protein-coupled receptor 88 isoform X1

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039103061.2 → XP_038958989.1 G protein-coupled receptor 88 isoform X1

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006233222.5 → XP_006233284.1 G protein-coupled receptor 88 isoform X1

See identical proteins and their annotated locations for XP_006233284.1

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006233221.5 → XP_006233283.1 G protein-coupled receptor 88 isoform X1

See identical proteins and their annotated locations for XP_006233283.1

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006233220.5 → XP_006233282.1 G protein-coupled receptor 88 isoform X1

See identical proteins and their annotated locations for XP_006233282.1

UniProtKB/Swiss-Prot

Q9ESP4

UniProtKB/TrEMBL

A6HV91

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily