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CDH24 cadherin 24 [ Homo sapiens (human) ]

Gene ID: 64403, updated on 11-Apr-2024

Summary

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Official Symbol
CDH24provided by HGNC
Official Full Name
cadherin 24provided by HGNC
Primary source
HGNC:HGNC:14265
See related
Ensembl:ENSG00000139880 MIM:618599; AllianceGenome:HGNC:14265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDH11L
Summary
Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Acts upstream of or within cell-cell adhesion. Located in cell-cell junction. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 4.3), gall bladder (RPKM 3.2) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
14q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23047067..23057520, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17247688..17258139, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23516276..23526729, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 5 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:23503835-23505034 Neighboring gene proteasome subunit beta 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23521379-23521879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5601 Neighboring gene collagen alpha-2(I) chain-like Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:23530845-23532044 Neighboring gene apoptotic chromatin condensation inducer 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23537671-23538195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8161 Neighboring gene uncharacterized LOC124903288 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:23547601-23548800

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability. An CH, et al. Pathol Oncol Res, 2015 Jan. PMID 24898286
  2. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. Katafiasz BJ, et al. J Biol Chem, 2003 Jul 25. PMID 12734196
  3. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. Hülsken J, et al. J Cell Biol, 1994 Dec. PMID 7806582, Free PMC Article
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unconventional CDH10, CDH24 and DCHS2 genes harbored frameshift mutations.
    Title: Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability.
  2. cadherin-24 is a novel alternatively spliced type II cadherin
    Title: Characterization of cadherin-24, a novel alternatively spliced type II cadherin.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25193, MGC131880

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cadherin-24
Names
cadherin 24, type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022478.4 → NP_071923.2  cadherin-24 isoform 1 precursor

    See identical proteins and their annotated locations for NP_071923.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY260901, BC009332, DC310509
    Consensus CDS
    CCDS9585.1
    UniProtKB/Swiss-Prot
    D3DS44, Q86UP0, Q86UP1, Q9NT84
    UniProtKB/TrEMBL
    A8K0L1
    Related
    ENSP00000380517.3, ENST00000397359.7
    Conserved Domains (4) summary
    cd11304
    Location:154 → 255
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:70 → 148
    CA; Cadherin repeats
    pfam01049
    Location:671 → 812
    Cadherin_C; Cadherin cytoplasmic region
    cl09101
    Location:521 → 615
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

  2. NM_144985.4 → NP_659422.2  cadherin-24 isoform 2

    See identical proteins and their annotated locations for NP_659422.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AY260900, AY358199, BC009332, DC310509
    Consensus CDS
    CCDS9586.1
    UniProtKB/TrEMBL
    A8K0L1
    Related
    ENSP00000434821.2, ENST00000487137.7
    Conserved Domains (4) summary
    cd11304
    Location:379 → 475
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:70 → 148
    CA; Cadherin repeats
    pfam01049
    Location:633 → 774
    Cadherin_C; Cadherin cytoplasmic region
    cl09101
    Location:483 → 577
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23047067..23057520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431697.1 → XP_047287653.1  cadherin-24 isoform X2

  2. XM_011537089.2 → XP_011535391.1  cadherin-24 isoform X1

    UniProtKB/TrEMBL
    Q96LQ7
    Conserved Domains (2) summary
    cd11304
    Location:154 → 255
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:70 → 148
    CA; Cadherin repeats

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17247688..17258139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376605.1 → XP_054232580.1  cadherin-24 isoform X2

  2. XM_054376604.1 → XP_054232579.1  cadherin-24 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UP0.1 GenPept UniProtKB/Swiss-Prot:Q86UP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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