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Aldh1l1 aldehyde dehydrogenase 1 family, member L1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64392, updated on 2-May-2024

Summary

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Official Symbol
Aldh1l1provided by RGD
Official Full Name
aldehyde dehydrogenase 1 family, member L1provided by RGD
Primary source
RGD:621294
See related
Ensembl:ENSRNOG00000047023 AllianceGenome:RGD:621294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FDH; Fthfd
Summary
Enables aldehyde dehydrogenase (NADP+) activity. Involved in bile acid signaling pathway. Part of protein-containing complex. Biomarker of cholestasis. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1007.9), Kidney (RPKM 533.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aldh1l1 in Genome Data Viewer
Location:
4q34
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124617182..124663674)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (123059989..123106471)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (123516553..123564067, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene KLF transcription factor 15 Neighboring gene uncharacterized LOC134486813 Neighboring gene uncharacterized LOC134486815 Neighboring gene solute carrier family 41, member 3 Neighboring gene IQ motif and Sec7 domain ArfGEF 1 Neighboring gene uncharacterized LOC134486814

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of putative tumor suppressor ALDH1L1. Tsybovsky Y, et al. Commun Biol, 2022 Jan 10. PMID 35013550, Free PMC Article
  2. Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases. Tsybovsky Y, et al. Biochemistry, 2007 Mar 20. PMID 17302434
  3. The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain. Chumanevich AA, et al. J Biol Chem, 2004 Apr 2. PMID 14729668
  4. Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase. Krupenko SA, et al. J Biol Chem, 1999 Dec 10. PMID 10585460
  5. Cysteine 707 is involved in the dehydrogenase activity site of rat 10-formyltetrahydrofolate dehydrogenase. Krupenko SA, et al. J Biol Chem, 1995 Jan 13. PMID 7822273

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
    Title: A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
  2. Structure of putative tumor suppressor ALDH1L1.
    Title: Structure of putative tumor suppressor ALDH1L1.
  3. catalytic mechanism for the hydrolase reaction in which Asp-142 polarizes the catalytic water molecule and His-106 orients the carbonyl group of formyl.
    Title: The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
  4. Upon binding of NADP+, side chain of Glu673 is displaced from the active site by the nicotinamide ring & contacts a chain of highly ordered water molecules that may represent a pathway for translocation of the abstracted proton from Glu673 to the solvent.
    Title: Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105431

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables formyltetrahydrofolate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formyltetrahydrofolate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables formyltetrahydrofolate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables formyltetrahydrofolate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables formyltetrahydrofolate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables formyltetrahydrofolate dehydrogenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 10-formyltetrahydrofolate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 10-formyltetrahydrofolate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 10-formyltetrahydrofolate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 10-formyltetrahydrofolate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH regeneration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NADPH regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in NADPH regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytosolic 10-formyltetrahydrofolate dehydrogenase
Names
10-FTHFDH
10-formyltetrahydrofolate dehydrogenase
FBP-CI
aldehyde dehydrogenase family 1 member L1
formyltetrahydrofolate dehydrogenase
NP_071992.2
XP_038964247.1
XP_063142735.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022547.2 → NP_071992.2  cytosolic 10-formyltetrahydrofolate dehydrogenase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P28037, Q5HZB2
    UniProtKB/TrEMBL
    A0A0G2K0D8
    Related
    ENSRNOP00000089314.1, ENSRNOT00000096748.1
    Conserved Domains (3) summary
    cd07140
    Location:417 → 902
    ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
    cd08647
    Location:1 → 203
    FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
    cd08703
    Location:206 → 306
    FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    124617182..124663674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286665.1 → XP_063142735.1  cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GG93

  2. XM_039108319.2 → XP_038964247.1  cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0D8
    Conserved Domains (3) summary
    cd08647
    Location:1 → 203
    FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
    cd08703
    Location:206 → 306
    FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
    cl11961
    Location:417 → 782
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28037.3 GenPept UniProtKB/Swiss-Prot:P28037

Gene LinkOut

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