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PGA3 pepsinogen A3 [ Homo sapiens (human) ]

Gene ID: 643834, updated on 3-Apr-2024

Summary

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Official Symbol
PGA3provided by HGNC
Official Full Name
pepsinogen A3provided by HGNC
Primary source
HGNC:HGNC:8885
See related
Ensembl:ENSG00000229859 MIM:169710; AllianceGenome:HGNC:8885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward stomach (RPKM 21519.3) See more
Orthologs
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Genomic context

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Location:
11q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61203515..61213098)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61155047..61164627)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60970987..60980570)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60902229-60902744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60902745-60903260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60904582-60905082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60905083-60905583 Neighboring gene VPS37C subunit of ESCRT-I Neighboring gene H3K27ac hESC enhancers GRCh37_chr11:60928361-60928954 and GRCh37_chr11:60928955-60929547 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:60933107-60933784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3386 Neighboring gene uncharacterized LOC124902678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60960971-60961472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60961473-60961972 Neighboring gene pepsinogen A4 Neighboring gene pepsinogen A5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran. Mansour-Ghanaei F, et al. Asian Pac J Cancer Prev, 2014. PMID 25292040
  2. Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions. Shafaghi A, et al. Asian Pac J Cancer Prev, 2013. PMID 23886209
  3. Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan. Abe Y, et al. J Gastroenterol Hepatol, 2009 Jan. PMID 19196398
  4. Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer. Li M, et al. Cell Mol Biol (Noisy-le-grand), 2021 Aug 31. PMID 34817333
  5. Significance of Serological Gastric Biopsy in Different Gastric Mucosal Lesions: an Observational Study. Dong Z, et al. Clin Lab, 2019 Dec 1. PMID 31414587

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer.
    Title: Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer.
  2. Serum pepsinogen (PG), gastrin, and Helicobacter pylori (H. pylori) IgG antibodies have become indicators for "serological biopsy" of the gastric mucosa lesion.
    Title: Significance of Serological Gastric Biopsy in Different Gastric Mucosal Lesions: an Observational Study.
  3. Low Pepsinogen I is associated with precancerous gastric lesions.
    Title: Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran.
  4. High serum Pepsinogen I level is associ9ated with the progression of gastric precancerous lesions.
    Title: Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.
  5. Significantly higher AUC was observed for the PGI/PGII ratio and is associated with atrophy and intestinal metaplasia.
    Title: Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions.
  6. A significant negative correlation was found between the degree of corpus atrophy and the level of serum pepsinogen-I in atrophic gastritis patients with gastroesophageal reflux.
    Title: Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study.
  7. Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan.
    Title: Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan.
  8. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer.
    Title: Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer.
  9. pepsinogens may have a role in esophageal squamous dysplasia
    Title: Serum pepsinogens and risk of esophageal squamous dysplasia.
  10. Higher levels of Pepsinogen I is associated with early gastric cancer
    Title: Histologic and serum risk markers for noncardia early gastric cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp666J2410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in multivesicular body lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
pepsin A-3
Names
pepsinogen 3, group I (pepsinogen A)
pepsinogen-3
NP_001073275.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079807.4 → NP_001073275.1  pepsin A-3 preproprotein

    See identical proteins and their annotated locations for NP_001073275.1

    Status: REVIEWED

    Source sequence(s)
    AK225679, AK312941, AP000437
    Consensus CDS
    CCDS31574.1
    UniProtKB/Swiss-Prot
    A8K749, B2R7D6, B7ZW75, P00790, P0DJD8, Q7M4R0, Q8N1E3
    UniProtKB/TrEMBL
    B7ZW16
    Related
    ENSP00000322192.6, ENST00000325558.11
    Conserved Domains (3) summary
    cd05478
    Location:66 → 386
    pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
    pfam00026
    Location:75 → 387
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:17 → 45
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61203515..61213098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61155047..61164627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DJD8.1 GenPept UniProtKB/Swiss-Prot:P0DJD8

Gene LinkOut

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