Itgad integrin subunit alpha D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgadprovided by RGD
Official Full Name: integrin subunit alpha Dprovided by RGD
Primary source: RGD:71075
See related: Ensembl:ENSRNOG00000068399 AllianceGenome:RGD:71075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Itgax
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in heterotypic cell-cell adhesion. Predicted to act upstream of or within activated T cell proliferation. Predicted to be part of integrin complex. Orthologous to human ITGAD (integrin subunit alpha D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 718.1), Thymus (RPKM 51.6) and 1 other tissue See more
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Genomic context

Location:: 1q37

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (192190204..192218864)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182759762..182788422)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199595968..199623931)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recovery from Antiglomerular Basement Membrane Glomerulonephritis Is Associated with Glomeruli-Infiltrating CD8alpha+CD11c+MHC Class II+ Cells
Title: Natural recovery from antiglomerular basement membrane glomerulonephritis is associated with glomeruli-infiltrating CD8α+CD11c+MHC class II+ cells.
An anti-CD11d monoclonal antibody improves motor performance, reduces pain and histopathological damage in animals following clip-compression injury.
Title: Anti-CD11d monoclonal antibody treatment for rat spinal cord compression injury.
CD11d expression increased in retroperitoneal white adipose tissue of Zucker obese rats.
Title: Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-D

Names: integrin alpha X (Cd11c)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031691.2 → NP_113879.2 integrin alpha-D precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I9Y5

Related

ENSRNOP00000071107.2, ENSRNOT00000085336.2

Conserved Domains (2) summary

smart00191
Location:455 → 511

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:151 → 326

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

192190204..192218864

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089555.2 → XP_038945483.1 integrin alpha-D isoform X1

UniProtKB/TrEMBL

A6I9Y5

Conserved Domains (4) summary

smart00191
Location:305 → 361

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:1 → 176

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:974 → 987

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:472 → 877

Integrin_alpha2; Integrin alpha
XM_039089549.2 → XP_038945477.1 integrin alpha-D isoform X1

UniProtKB/TrEMBL

A6I9Y5

Conserved Domains (4) summary

smart00191
Location:305 → 361

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:1 → 176

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:974 → 987

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:472 → 877

Integrin_alpha2; Integrin alpha