Acads acyl-CoA dehydrogenase short chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acadsprovided by RGD
Official Full Name: acyl-CoA dehydrogenase short chainprovided by RGD
Primary source: RGD:620514
See related: Ensembl:ENSRNOG00000001177 AllianceGenome:RGD:620514
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Scad
Summary: Enables identical protein binding activity; nucleotide binding activity; and oxidoreductase activity, acting on the CH-CH group of donors. Involved in fatty acid catabolic process; response to glucocorticoid; and response to starvation. Located in mitochondrial matrix and mitochondrial membrane. Human ortholog(s) of this gene implicated in short chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADS (acyl-CoA dehydrogenase short chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 801.2), Liver (RPKM 383.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (47154259..47163580)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41493650..41502897)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47254503..47263747)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Title: Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
the role of SCAD in tert-butyl hydroperoxide (tBHP)-induced cardiomyocyte apoptosis, is reported.
Title: Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte apoptosis.
the down-regulated expression of SCAD in pathological cardiac hypertrophy may be responsible for 'the recapitulation of foetal energy metabolism'.
Title: Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress.
the phosphorylation of ERK1/2 inhibited the expression and activity of SCAD through the PPARalpha signaling pathway, which induced the development of pathological cardiomyocyte hypertrophy.
Title: Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.
Title: Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134326 (e-PCR)
- UniSTS:217608

Acads (e-PCR), detects polymorphism
- UniSTS:546622

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables acyl-CoA dehydrogenase activity	NAS Non-traceable Author Statement more info	PubMed
enables butyryl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables butyryl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables butyryl-CoA dehydrogenase activity	TAS Traceable Author Statement more info	PubMed
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in butyrate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in butyrate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: short-chain specific acyl-CoA dehydrogenase, mitochondrial

Names: acetyl-Coenzyme A dehydrogenase, short chain; acyl-CoA dehydrogenase, C-2 to C-3 short chain; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; acyl-Coenzyme A dehydrogenase, short chain; butyryl-CoA dehydrogenase; short chain acyl-coenzyme A dehydrogenase; short-chain acyl-CoA dehydrogenase

NP_071957.1

EC 1.3.8.1

XP_063127684.1

EC 1.3.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022512.2 → NP_071957.1 short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_071957.1

Status: PROVISIONAL

Source sequence(s)

J05030

UniProtKB/Swiss-Prot

P15651

UniProtKB/TrEMBL

Q6IMX3

Related

ENSRNOP00000001556.4, ENSRNOT00000001556.5

Conserved Domains (2) summary

cd01158
Location:38 → 410

SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases

COG1960
Location:35 → 414

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]