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aox5 aldehyde oxidase 5 [ Danio rerio (zebrafish) ]

Gene ID: 64265, updated on 27-Mar-2024

Summary

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Official Symbol
aox5provided by ZNC
Official Full Name
aldehyde oxidase 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-001205-2
See related
Ensembl:ENSDARG00000071475 AllianceGenome:ZFIN:ZDB-GENE-001205-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
xdh; aox3; fc18g02; wu:fc18g02; etID47878.22
Summary
Predicted to enable aldehyde oxidase activity. Located in cytoplasm. Is expressed in several structures, including fin; neural crest; pigment cell; post-vent region; and xanthoblast. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 22
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (14084036..14115316, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (14059259..14090539, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 4Ca Neighboring gene aldehyde oxidase 6 Neighboring gene si:ch211-246m6.4 Neighboring gene hatching enzyme 1, tandem duplicate 1 Neighboring gene hatching enzyme 1, tandem dupliate 2 Neighboring gene si:ch211-246m6.5 Neighboring gene hatching enzyme 1, tandem duplicate 3 Neighboring gene basic leucine zipper and W2 domains 1a Neighboring gene uncharacterized LOC101883810

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Larval but not adult xanthophore pigmentation in zebrafish requires GTP cyclohydrolase 2 (gch2) function. Lister JA. Pigment Cell Melanoma Res, 2019 Sep. PMID 30896066
  2. Method for disarranging the pigment pattern of zebrafish by optogenetics. Aramaki T, et al. Dev Biol, 2020 Apr 1. PMID 30578760
  3. Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. McMenamin SK, et al. Science, 2014 Sep 12. PMID 25170046, Free PMC Article
  4. Melanophore migration and survival during zebrafish adult pigment stripe development require the immunoglobulin superfamily adhesion molecule Igsf11. Eom DS, et al. PLoS Genet, 2012. PMID 22916035, Free PMC Article
  5. Zebrafish endzone regulates neural crest-derived chromatophore differentiation and morphology. Arduini BL, et al. PLoS One, 2008 Jul 30. PMID 18665240, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables xanthine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables xanthine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aldehyde oxidase 5
Names
aldehyde oxidase 3
aldehyde oxidase alpha
aox alpha
aox2
aoxa
xanthene dehydrogenase
NP_001265725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278796.1 → NP_001265725.1  aldehyde oxidase 5

    See identical proteins and their annotated locations for NP_001265725.1

    Status: PROVISIONAL

    Source sequence(s)
    BK008657
    UniProtKB/TrEMBL
    A0A8M1P013, M1ZMM0
    Related
    ENSDARP00000134334.1, ENSDART00000165670.2
    Conserved Domains (6) summary
    TIGR02969
    Location:8 → 1336
    mam_aldehyde_ox; aldehyde oxidase
    smart01008
    Location:591 → 696
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam00941
    Location:237 → 417
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01799
    Location:91 → 162
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:718 → 1243
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:424 → 528
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    14084036..14115316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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