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TFB2M transcription factor B2, mitochondrial [ Homo sapiens (human) ]

Gene ID: 64216, updated on 4-Jan-2025

Summary

Official Symbol
TFB2Mprovided by HGNC
Official Full Name
transcription factor B2, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:18559
See related
Ensembl:ENSG00000162851 MIM:607055; AllianceGenome:HGNC:18559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hkp1; hTFB2M; mtTFB2; h-mtTFB; h-mtTFB2
Summary
Enables mitochondrial transcription factor activity. Involved in transcription initiation at mitochondrial promoter. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in adrenal (RPKM 13.7), kidney (RPKM 9.8) and 25 other tissues See more
Orthologs
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Genomic context

See TFB2M in Genome Data Viewer
Location:
1q44
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (246540561..246566261, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (245961432..245987151, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (246703863..246729563, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246487577-246488097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2031 Neighboring gene SMYD3 intronic transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246518331-246518956 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:246533672-246533878 Neighboring gene MPRA-validated peak812 silencer Neighboring gene Sharpr-MPRA regulatory region 15017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246591613-246592114 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246592115-246592614 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:246612672-246613232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246670033-246670533 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:246671208-246671440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246669532-246670032 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:246679947-246680127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246701627-246702127 Neighboring gene long intergenic non-protein coding RNA 1743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2857 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:246762689-246762876 Neighboring gene uncharacterized LOC105373271 Neighboring gene consortin, connexin sorting protein Neighboring gene ribosomal protein L7a pseudogene 82

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ22661, FLJ23182

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in mitochondrial matrix  
located_in mitochondrial matrix PubMed 
located_in mitochondrial matrix PubMed 
located_in mitochondrial matrix  
located_in mitochondrial nucleoid PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion  

General protein information

Preferred Names
dimethyladenosine transferase 2, mitochondrial
Names
HCV NS5A-transactivated protein 5
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
hepatitis C virus NS5A-transactivated protein 5
mitochondrial 12S rRNA dimethylase 2
mitochondrial transcription factor B2
NP_071761.1
XP_011542550.1
XP_054194141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022366.3NP_071761.1  dimethyladenosine transferase 2, mitochondrial

    See identical proteins and their annotated locations for NP_071761.1

    Status: VALIDATED

    Source sequence(s)
    AK026835, CK725134, DA038232
    Consensus CDS
    CCDS1627.1
    UniProtKB/Swiss-Prot
    Q9H5Q4, Q9H626
    Related
    ENSP00000355471.4, ENST00000366514.5
    Conserved Domains (1) summary
    cl17173
    Location:94379
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    246540561..246566261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544248.2XP_011542550.1  dimethyladenosine transferase 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011542550.1

    Conserved Domains (1) summary
    cl17173
    Location:94278
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    245961432..245987151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338166.1XP_054194141.1  dimethyladenosine transferase 2, mitochondrial isoform X1

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