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Adgrl4 adhesion G protein-coupled receptor L4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64124, updated on 2-May-2024

Summary

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Official Symbol
Adgrl4provided by RGD
Official Full Name
adhesion G protein-coupled receptor L4provided by RGD
Primary source
RGD:621136
See related
Ensembl:ENSRNOG00000033940 AllianceGenome:RGD:621136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Etl; Eltd1
Summary
Predicted to enable G protein-coupled receptor activity. Involved in protein-containing complex assembly. Located in cytoplasmic vesicle and plasma membrane. Biomarker of glioblastoma. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 175.8), Kidney (RPKM 171.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q45
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243014927..243117226)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (240354909..240457231)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (256609787..256724642)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691735 Neighboring gene uncharacterized LOC134486008 Neighboring gene uncharacterized LOC102548445 Neighboring gene interferon-induced protein 44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Ziegler J, et al. Neuro Oncol, 2017 Feb 1. PMID 27416955, Free PMC Article
  2. ELTD1, a potential new biomarker for gliomas. Towner RA, et al. Neurosurgery, 2013 Jan. PMID 23096411, Free PMC Article
  3. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. Xiao J, et al. PLoS One, 2012. PMID 22606234, Free PMC Article
  4. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. Nechiporuk T, et al. J Biol Chem, 2001 Feb 9. PMID 11050079
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor L4
Names
EGF, latrophilin and seven transmembrane domain containing 1
EGF, latrophilin and seven transmembrane domain-containing protein 1
EGF, latrophilin seven transmembrane domain containing 1
EGF-TM7-latrophilin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022294.1 → NP_071630.1  adhesion G protein-coupled receptor L4 precursor

    See identical proteins and their annotated locations for NP_071630.1

    Status: PROVISIONAL

    Source sequence(s)
    AF192401
    UniProtKB/Swiss-Prot
    Q9ESC0, Q9ESC1
    UniProtKB/TrEMBL
    A0A8L2R476, A6HWI6
    Related
    ENSRNOP00000071560.2, ENSRNOT00000088437.2
    Conserved Domains (4) summary
    smart00179
    Location:57 → 90
    EGF_CA; Calcium-binding EGF-like domain
    pfam01825
    Location:416 → 460
    GPS; GPCR proteolysis site, GPS, motif
    pfam16489
    Location:188 → 365
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:472 → 708
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    243014927..243117226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103036.2 → XP_038958964.1  adhesion G protein-coupled receptor L4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R476
    Conserved Domains (5) summary
    smart00179
    Location:57 → 90
    EGF_CA; Calcium-binding EGF-like domain
    pfam01825
    Location:366 → 410
    GPS; GPCR proteolysis site, GPS, motif
    pfam16489
    Location:136 → 312
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:424 → 449
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:422 → 679
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESC1.1 GenPept UniProtKB/Swiss-Prot:Q9ESC1

Gene LinkOut

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