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Gpr35 G protein-coupled receptor 35 [ Mus musculus (house mouse) ]

Gene ID: 64095, updated on 2-May-2024

Summary

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Official Symbol
Gpr35provided by MGI
Official Full Name
G protein-coupled receptor 35provided by MGI
Primary source
MGI:MGI:1929509
See related
Ensembl:ENSMUSG00000026271 AllianceGenome:MGI:1929509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KPG_007
Summary
Predicted to enable C-X-C chemokine receptor activity. Involved in cytoskeleton organization. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in gut and lower urinary tract. Orthologous to human GPR35 (G protein-coupled receptor 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 5.6), spleen adult (RPKM 3.2) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 D; 1 46.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92875774..92913984)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92948052..92986391)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene arginyl aminopeptidase (aminopeptidase B)-like 1 Neighboring gene STARR-seq mESC enhancer starr_01722 Neighboring gene RIKEN cDNA 9430060I03 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:94830898-94831081 Neighboring gene STARR-positive B cell enhancer ABC_E4335 Neighboring gene calpain 10 Neighboring gene predicted gene, 36424 Neighboring gene trans-acting transcription factor 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gpr35 shapes gut microbial ecology to modulate hepatic steatosis. Wu X, et al. Pharmacol Res, 2023 Mar. PMID 36758734
  2. Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. Melhem H, et al. Mucosal Immunol, 2022 Mar. PMID 35264769, Free PMC Article
  3. Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway. Wang Y, et al. Toxicol Appl Pharmacol, 2022 Mar 1. PMID 35123988
  4. G-Protein Coupled Receptor 35 Induces Intervertebral Disc Degeneration by Mediating the Influx of Calcium Ions and Upregulating Reactive Oxygen Species. Chen Z, et al. Oxid Med Cell Longev, 2022. PMID 35087615, Free PMC Article
  5. Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure. Li H, et al. Hypertension, 2021 Sep. PMID 34275335, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior.
    Title: A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior.
  2. Gpr35 shapes gut microbial ecology to modulate hepatic steatosis.
    Title: Gpr35 shapes gut microbial ecology to modulate hepatic steatosis.
  3. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
    Title: Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
  4. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
    Title: GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
  5. Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity.
    Title: Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity.
  6. Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-kappaB signaling pathway.
    Title: Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway.
  7. GPR35 regulates osteogenesis via the Wnt/GSK3beta/beta-catenin signaling pathway.
    Title: GPR35 regulates osteogenesis via the Wnt/GSK3β/β-catenin signaling pathway.
  8. Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1(+) Macrophages Regulates Intestinal Homeostasis.
    Title: Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1(+) Macrophages Regulates Intestinal Homeostasis.
  9. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.
    Title: Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.
  10. Data suggest that G protein-coupled receptor 35 (GPR35 ) acts as a central signaling and metabolic pacesetter, which reveals an unexpected role of sodium potassium pump (Na/K-ATPase) in macrophage and intestinal epithelial cells (IECs) biology.
    Title: GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 35
Names
KYNA receptor
kynurenic acid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104529.2 → NP_001097999.1  G-protein coupled receptor 35

    See identical proteins and their annotated locations for NP_001097999.1

    Status: VALIDATED

    Source sequence(s)
    AC119846
    Consensus CDS
    CCDS15182.1
    UniProtKB/Swiss-Prot
    Q9ES90
    UniProtKB/TrEMBL
    Q3TBY9, Q8CB97
    Related
    ENSMUSP00000139648.2, ENSMUST00000186298.7
    Conserved Domains (1) summary
    cd15164
    Location:35 → 286
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001271766.2 → NP_001258695.1  G-protein coupled receptor 35

    See identical proteins and their annotated locations for NP_001258695.1

    Status: VALIDATED

    Source sequence(s)
    AC119846
    Consensus CDS
    CCDS15182.1
    UniProtKB/Swiss-Prot
    Q9ES90
    UniProtKB/TrEMBL
    Q3TBY9, Q8CB97
    Related
    ENSMUSP00000070832.7, ENSMUST00000064480.7
    Conserved Domains (1) summary
    cd15164
    Location:35 → 286
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001412853.1 → NP_001399782.1  G-protein coupled receptor 35

    Status: VALIDATED

    Source sequence(s)
    AC119846
    UniProtKB/Swiss-Prot
    Q9ES90
    UniProtKB/TrEMBL
    Q3TBY9

  4. NM_022320.5 → NP_071715.3  G-protein coupled receptor 35

    See identical proteins and their annotated locations for NP_071715.3

    Status: VALIDATED

    Source sequence(s)
    AC119846
    Consensus CDS
    CCDS15182.1
    UniProtKB/Swiss-Prot
    Q9ES90
    UniProtKB/TrEMBL
    Q3TBY9, Q8CB97
    Related
    ENSMUSP00000126914.2, ENSMUST00000169198.3
    Conserved Domains (1) summary
    cd15164
    Location:35 → 286
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    92875774..92913984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529780.4 → XP_006529843.1  G-protein coupled receptor 35 isoform X2

    See identical proteins and their annotated locations for XP_006529843.1

    UniProtKB/Swiss-Prot
    Q9ES90
    UniProtKB/TrEMBL
    Q3TBY9, Q8CB97
    Conserved Domains (1) summary
    cd15164
    Location:35 → 286
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_011248053.4 → XP_011246355.1  G-protein coupled receptor 35 isoform X2

    See identical proteins and their annotated locations for XP_011246355.1

    UniProtKB/Swiss-Prot
    Q9ES90
    UniProtKB/TrEMBL
    Q3TBY9, Q8CB97
    Conserved Domains (1) summary
    cd15164
    Location:35 → 286
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_006529777.4 → XP_006529840.1  G-protein coupled receptor 35 isoform X1

    UniProtKB/TrEMBL
    Q8CB97
    Conserved Domains (1) summary
    cd15164
    Location:41 → 292
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_006529779.5 → XP_006529842.1  G-protein coupled receptor 35 isoform X2

    See identical proteins and their annotated locations for XP_006529842.1

    UniProtKB/Swiss-Prot
    Q9ES90
    UniProtKB/TrEMBL
    Q3TBY9, Q8CB97
    Conserved Domains (1) summary
    cd15164
    Location:35 → 286
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES90.1 GenPept UniProtKB/Swiss-Prot:Q9ES90

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