Aldh9a1 aldehyde dehydrogenase 9 family, member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Aldh9a1provided by RGD
Full Name: aldehyde dehydrogenase 9 family, member A1provided by RGD
Primary source: RGD:68409
See related: Ensembl:ENSRNOG00000004027 AllianceGenome:RGD:68409
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmaba-dh
Summary: Enables several functions, including NAD binding activity; identical protein binding activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Involved in kidney development and liver development. Located in cytosol. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1093.3), Kidney (RPKM 762.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (82038679..82055478)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (79505738..79522539)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (85580828..85597497)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMABA-DH colocalized with myosin light chains in cardiac myocytes.
Title: Identification of 4-Trimethylaminobutyraldehyde Dehydrogenase (TMABA-DH) as a Candidate Serum Autoantibody Target for Kawasaki Disease.
Foetuses express TMABA-DH mRNA and this expression increased during postnatal life
Title: Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-pyrroline dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables amine binding	IDA Inferred from Direct Assay more info	PubMed
enables aminobutyraldehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminobutyraldehyde dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables aminobutyraldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables formaldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables formaldehyde dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carnitine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in carnitine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in carnitine biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within carnitine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular aldehyde metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular aldehyde metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 4-trimethylaminobutyraldehyde dehydrogenase

Names: 4-trimethylaminobutyraldehyde dehydrogenase-like; TMABADH; aldehyde dehydrogenase 9A1; aldehyde dehydrogenase family 9 member A1; aldehyde dehydrogenase family 9, subfamily A1; formaldehyde dehydrogenase; gamma-aminobutyraldehyde dehydrogenase; gamma-trimethylaminobutyraldehyde dehydrogenase

NP_071609.2

EC 1.2.1.19

EC 1.2.1.3

EC 1.2.1.46

EC 1.2.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022273.2 → NP_071609.2 4-trimethylaminobutyraldehyde dehydrogenase

See identical proteins and their annotated locations for NP_071609.2

Status: PROVISIONAL

Source sequence(s)

BC074019

UniProtKB/Swiss-Prot

Q6GMM4, Q9JLJ3

UniProtKB/TrEMBL

A0A8I6AQJ5

Related

ENSRNOP00000005611.6, ENSRNOT00000005611.6

Conserved Domains (1) summary

cd07090
Location:31 → 488

ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1