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Cd55 CD55 molecule (Cromer blood group) [ Rattus norvegicus (Norway rat) ]

Gene ID: 64036, updated on 4-Jan-2025

Summary

Official Symbol
Cd55provided by RGD
Official Full Name
CD55 molecule (Cromer blood group)provided by RGD
Primary source
RGD:620651
See related
EnsemblRapid:ENSRNOG00000003927 AllianceGenome:RGD:620651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Daf; Daf1
Summary
Enables enzyme inhibitor activity. Involved in several processes, including maternal process involved in parturition; negative regulation of complement activation; and response to peptide hormone. Located in apical plasma membrane. Used to study neuroblastoma and proteinuria. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 104.8), Lung (RPKM 66.1) and 8 other tissues See more
Orthologs
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Genomic context

See Cd55 in Genome Data Viewer
Location:
13q13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (44409574..44438913, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (41857242..41885966, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47125156..47153557, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 7B Neighboring gene uncharacterized LOC134481489 Neighboring gene mitochondrial ribosomal protein L30, pseudogene 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene zona pellucida 3 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme inhibitor activity PubMed 
enables lipid binding  
enables virus receptor activity  
Process Evidence Code Pubs
involved_in maternal process involved in parturition PubMed 
involved_in negative regulation of complement activation PubMed 
involved_in negative regulation of complement activation  
involved_in positive regulation of CD4-positive, alpha-beta T cell activation  
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation  
involved_in positive regulation of T cell cytokine production  
involved_in positive regulation of cytosolic calcium ion concentration  
acts_upstream_of_or_within regulation of complement activation  
acts_upstream_of_or_within regulation of complement activation, classical pathway  
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity  
involved_in regulation of lipopolysaccharide-mediated signaling pathway  
involved_in response to peptide hormone PubMed 
involved_in spermatogenesis PubMed 
involved_in symbiont entry into host cell  
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in cell surface  
located_in external side of plasma membrane  
located_in membrane raft  
located_in plasma membrane  
located_in sperm midpiece  

General protein information

Preferred Names
complement decay-accelerating factor
Names
CD55 antigen
CD55 molecule, decay accelerating factor for complement
decay accelarating factor 1
decay accelerating factor 1
decay accelerating factor GPI-form
decay-accelarating factor
glycosylphophatidylinositol-anchored form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022269.2NP_071605.2  complement decay-accelerating factor precursor

    See identical proteins and their annotated locations for NP_071605.2

    Status: VALIDATED

    Source sequence(s)
    BC061869, CB610207
    UniProtKB/TrEMBL
    A0A0G2QC50, A0A9K3Y778, G3V6H8, Q9QUN6, Q9Z0M0
    Related
    ENSRNOP00000005284.7, ENSRNOT00000005284.8
    Conserved Domains (2) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    44409574..44438913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272578.1XP_063128648.1  complement decay-accelerating factor isoform X5

    UniProtKB/TrEMBL
    A9CMA5
  2. XM_063272577.1XP_063128647.1  complement decay-accelerating factor isoform X3

    UniProtKB/TrEMBL
    Q9QUN6
    Related
    ENSRNOP00000079102.2, ENSRNOT00000097302.2
  3. XM_063272579.1XP_063128649.1  complement decay-accelerating factor isoform X8

    UniProtKB/TrEMBL
    A6IBX9
  4. XM_017598924.3XP_017454413.1  complement decay-accelerating factor isoform X10

    UniProtKB/TrEMBL
    A9CMA5
  5. XM_006249723.5XP_006249785.1  complement decay-accelerating factor isoform X9

    UniProtKB/TrEMBL
    Q9QUN6
    Conserved Domains (2) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
  6. XM_017598923.3XP_017454412.1  complement decay-accelerating factor isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZMB7, A6IBX8, Q9QUN6
    Conserved Domains (2) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
  7. XM_039091062.2XP_038946990.1  complement decay-accelerating factor isoform X6

    UniProtKB/TrEMBL
    Q9QUT3
    Conserved Domains (2) summary
    cd00033
    Location:3694
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:94283
    PHA02927; secreted complement-binding protein; Provisional
  8. XM_006249719.5XP_006249781.1  complement decay-accelerating factor isoform X7

    See identical proteins and their annotated locations for XP_006249781.1

    UniProtKB/TrEMBL
    A6IBY0, Q9QUT3
    Conserved Domains (2) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
  9. XM_008769498.4XP_008767720.1  complement decay-accelerating factor isoform X11

    UniProtKB/TrEMBL
    Q9QUT3
    Conserved Domains (2) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
  10. XM_063272576.1XP_063128646.1  complement decay-accelerating factor isoform X1

  11. XM_006249717.5XP_006249779.1  complement decay-accelerating factor isoform X2

    See identical proteins and their annotated locations for XP_006249779.1

    UniProtKB/TrEMBL
    Q9Z0L9
    Conserved Domains (2) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
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