Pygl glycogen phosphorylase L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pyglprovided by RGD
Official Full Name: glycogen phosphorylase Lprovided by RGD
Primary source: RGD:620687
See related: Ensembl:ENSRNOG00000006388 AllianceGenome:RGD:620687
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables carbohydrate binding activity; glycogen phosphorylase activity; and identical protein binding activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process and glycogen catabolic process. Located in cytoplasm. Used to study glycogen storage disease VI and lactic acidosis. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 825.9), Thymus (RPKM 319.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (94433558..94476219, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (88697598..88740260, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (92597759..92643734, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that two biomarkers, glycine N-methyltransferase (GNMT) and glycogen phosphorylase (PYGL), were found to indicate early hepatic injuries.
Title: Proteomic investigation of signatures for geniposide-induced hepatotoxicity.
Data show that inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Title: Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Liver-type glycogen phosphorylase can also catalyze reduction of arsenate.
Title: Glutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors.
Results suggest that a signalling pathway involving dephosphorylation of phosphorylase a, leading to both activation and translocation of glycogen synthase, is a critical component of the mechanism by which insulin stimulates hepatic glycogen synthesis.
Title: Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.
glycogen phosphorylase is inactivated in liver cells by glucose
Title: Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.
glycogen phosphorylase has a role in 5-phosphoribosyl-1-pyrophosphate generation in liver tissue in the basal (postabsorptive) state
Title: Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures.
study on inhibition of glycogen phosphorylase
Title: Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables SHG alpha-glucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables bile acid binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables glucose binding	ISO Inferred from Sequence Orthology more info
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycogen phosphorylase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables linear malto-oligosaccharide phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables purine nucleobase binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within necroptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycogen phosphorylase, liver form

Names: liver glycogen phosphorylase; phosphorylase, glycogen, liver

NP_071604.1

EC 2.4.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022268.1 → NP_071604.1 glycogen phosphorylase, liver form

See identical proteins and their annotated locations for NP_071604.1

Status: PROVISIONAL

Source sequence(s)

X63515

UniProtKB/Swiss-Prot

P09811

UniProtKB/TrEMBL

A6HBY8

Related

ENSRNOP00000009183.3, ENSRNOT00000009183.6

Conserved Domains (2) summary

cd04300
Location:29 → 827

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:32 → 827

P_ylase; glycogen/starch/alpha-glucan phosphorylases