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Gpr85 G protein-coupled receptor 85 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64020, updated on 30-Mar-2024

Summary

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Official Symbol
Gpr85provided by RGD
Official Full Name
G protein-coupled receptor 85provided by RGD
Primary source
RGD:71011
See related
Ensembl:ENSRNOG00000024636 AllianceGenome:RGD:71011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SREB2; Srep2; PKrCx1
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human GPR85 (G protein-coupled receptor 85). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 63.4) and Uterus (RPKM 16.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
4q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (43070194..43075662, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (42100138..42109584, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (40377705..40387147, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene base methyltransferase of 25S rRNA 2 homolog Neighboring gene uncharacterized LOC120102155 Neighboring gene small integral membrane protein 30 like 1 Neighboring gene fatty acid-binding protein, heart-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Matsumoto M, et al. Brain Res Mol Brain Res, 2005 Jul 29. PMID 15893849
  2. The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis. Fujita-Jimbo E, et al. Mol Autism, 2015. PMID 25780553, Free PMC Article
  3. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833454
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC105281

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 85
Names
Super Conserved Receptor Expressed in Brain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022254.4 → NP_071590.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_071590.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P60895
    UniProtKB/TrEMBL
    A6IE06
    Related
    ENSRNOP00000031780.3, ENSRNOT00000039005.6
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    43070194..43075662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236126.5 → XP_006236188.1  probable G-protein coupled receptor 85 isoform X1

    See identical proteins and their annotated locations for XP_006236188.1

    UniProtKB/Swiss-Prot
    P60895
    UniProtKB/TrEMBL
    A6IE06
    Related
    ENSRNOP00000084618.1
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006236124.5 → XP_006236186.1  probable G-protein coupled receptor 85 isoform X1

    See identical proteins and their annotated locations for XP_006236186.1

    UniProtKB/Swiss-Prot
    P60895
    UniProtKB/TrEMBL
    A6IE06
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_017592861.3 → XP_017448350.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60895
    UniProtKB/TrEMBL
    A6IE06
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_017592860.3 → XP_017448349.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60895
    UniProtKB/TrEMBL
    A6IE06
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60895.1 GenPept UniProtKB/Swiss-Prot:P60895

Gene LinkOut

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