Xiap X-linked inhibitor of apoptosis [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Xiapprovided by RGD
Full Name: X-linked inhibitor of apoptosisprovided by RGD
Primary source: RGD:620692
See related: Ensembl:ENSRNOG00000006967 AllianceGenome:RGD:620692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Api3; Birc4; riap3
Summary: Enables protease binding activity and scaffold protein binding activity. Involved in negative regulation of neuron apoptotic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 202.3), Lung (RPKM 186.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (125756107..125803979)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (120890537..120938413)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (128409425..128455786)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP.
Title: SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP.
MicroRNA-130a regulates neurological deficit and angiogenesis in rats with ischaemic stroke by targeting XIAP.
Title: MicroRNA-130a regulates neurological deficit and angiogenesis in rats with ischaemic stroke by targeting XIAP.
Effects of Different Degrees of Carotid Artery Stenosis on the Expression of XIAP and Smac in the Ischemic Penumbra of Rats with Cerebral Ischemia-Reperfusion.
Title: Effects of Different Degrees of Carotid Artery Stenosis on the Expression of XIAP and Smac in the Ischemic Penumbra of Rats with Cerebral Ischemia-Reperfusion.
These results show that XIAP acts as an endogenous neuroprotective and anti-apoptotic agent following SAH. The effects of XIAP on early brain injury was associated with the inhibition of the caspase-dependent apoptosis pathway.
Title: X-linked inhibitor of apoptosis inhibits apoptosis and preserves the blood-brain barrier after experimental subarachnoid hemorrhage.
Data suggest that cerebral ischemia-reperfusion induces a transnitrosylation from procaspase-9 to X-linked inhibitor of apoptosis protein (XIAP) via the Trx system to consequently cause apoptosis.
Title: Procaspase-9 induces its cleavage by transnitrosylating XIAP via the Thioredoxin system during cerebral ischemia-reperfusion in rats.
Cognitive impairment and hippocampal neuron apoptosis can cause glucose and lipids metabolic abnormalities, possibly by regulating gastrointestinal motility and AMPK expression in the liver. The changes in the function of XIAP, which is an anti-apoptotic protein in the hippocampus, may affect the metabolism of glucose and lipids.
Title: The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats.
HSP72 preserves renal function in I/R injury through its antiapoptotic effects, which act by suppressing mitochondrial Smac/Diablo release and preserving XIAP protein content.
Title: Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury.
The results of this study showed that Endogenous XIAP modulates cerebellar granule neurons survival.
Title: Endogenous XIAP, but not other members of the inhibitory apoptosis protein family modulates cerebellar granule neurons survival.
CCN1, often co-expressed with FasL in a stressed heart, sensitizes cardiomyoblasts to FasL-induced apoptosis by activating the mitochondrial pathway to dismantle XIAP.
Title: CCN1 enables Fas ligand-induced apoptosis in cardiomyoblast H9c2 cells by disrupting caspase inhibitor XIAP.
The overexpression of pro-survival XIAP and IAP-1 in the retinas was not associated with similar changes in the optic nerves of glaucomatous eyes. This may explain the increased vulnerability of optic nerves to elevated intraocular pressure.
Title: Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables endopeptidase regulator activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase regulator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein linear polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein linear polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein linear polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptosis involved in tissue homeostasis	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptosis involved in tissue homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase XIAP

Names: IAP homolog A; IAP-3; RIAP-3; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; X-linked inhibitor of apoptosis protein; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase; apoptosis inhibitor protein 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; inhibitor of apoptosis protein 3

NP_071567.1

EC 2.3.2.27

XP_006257568.1

EC 2.3.2.27

XP_006257571.1

EC 2.3.2.27

XP_038955946.1

EC 2.3.2.27

XP_063136347.1

EC 2.3.2.27

XP_063136348.1

EC 2.3.2.27

XP_063136349.1

EC 2.3.2.27

XP_063136350.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022231.2 → NP_071567.1 E3 ubiquitin-protein ligase XIAP

See identical proteins and their annotated locations for NP_071567.1

Status: VALIDATED

Source sequence(s)

AB033366, AC111718

UniProtKB/Swiss-Prot

Q9R0I6

UniProtKB/TrEMBL

A0A0G2K4S8, A6JMM4, Q9ESF0

Related

ENSRNOP00000009336.2, ENSRNOT00000009336.4

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

125756107..125803979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280279.1 → XP_063136349.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

Q9R0I6

UniProtKB/TrEMBL

A6JMM4
XM_063280277.1 → XP_063136347.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

Q9R0I6

UniProtKB/TrEMBL

A6JMM4
XM_063280278.1 → XP_063136348.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

Q9R0I6

UniProtKB/TrEMBL

A6JMM4
XM_063280280.1 → XP_063136350.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

Q9R0I6

UniProtKB/TrEMBL

A6JMM4
XM_006257509.5 → XP_006257571.1 E3 ubiquitin-protein ligase XIAP isoform X2

See identical proteins and their annotated locations for XP_006257571.1

UniProtKB/Swiss-Prot

Q9R0I6

UniProtKB/TrEMBL

A0A0G2K4S8, A6JMM4, Q9ESF0

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_006257506.5 → XP_006257568.1 E3 ubiquitin-protein ligase XIAP isoform X1

UniProtKB/TrEMBL

A0A0G2K019, A6JMM2

Related

ENSRNOP00000071268.2

Conserved Domains (4) summary

smart00238
Location:202 → 272

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:68 → 135

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:409 → 458

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

pfam13920
Location:485 → 528

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
XM_039100018.2 → XP_038955946.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

Q9R0I6

UniProtKB/TrEMBL

A0A0G2K4S8, A6JMM4, Q9ESF0

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins