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P2ry4 pyrimidinergic receptor P2Y4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63843, updated on 3-Apr-2024

Summary

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Official Symbol
P2ry4provided by RGD
Official Full Name
pyrimidinergic receptor P2Y4provided by RGD
Primary source
RGD:61798
See related
Ensembl:ENSRNOG00000070777 AllianceGenome:RGD:61798
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P2Y4
Summary
Enables ATP binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 16.9), Lung (RPKM 14.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (69722604..69757726, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (65681680..65717404, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (70421599..70447109, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol O-acyltransferase 2-like 6 Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene arrestin 3 Neighboring gene uncharacterized LOC120099344 Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE. Dosh RH, et al. Wiad Lek, 2022. PMID 36591760
  2. Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways. Szrejder M, et al. Arch Biochem Biophys, 2020 Nov 30. PMID 33122160
  3. Localization and possible function of P2Y(4) receptors in the rodent retina. Ward MM, et al. Neuroscience, 2008 Sep 9. PMID 18625291
  4. Changes in P2Y4 receptor expression in rat cochlear outer sulcus cells during development. Lee JH, et al. Hear Res, 2007 Jun. PMID 17433586
  5. Molecular cloning and characterization of the rat P2Y4 receptor. Webb TE, et al. J Neurochem, 1998 Oct. PMID 9751165

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE.
    Title: IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE.
  2. Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways.
    Title: Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways.
  3. Activation of renal medullary P2Y2/P2Y4 receptors promotes ET-1-dependent natriuresis in ovariectomized rats.
    Title: Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.
  4. in 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by R2Y2 receptors. R2Y4 receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups
    Title: Involvement of P2Y(2,4) receptors in the regulation of myocardial contractility in growing rats.
  5. Amyloid precursor protein (APP) production and secretion is regulated by activation of P2Y2/4 receptors coupled to protein kinase signaling pathways, in a demonstration using astrocytes as a potential source of APP.
    Title: P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes.
  6. P2Y2 and P2Y4 receptors in granulosa cells modulate Cl- permeability by regulating Ca2+-release.
    Title: Purinergic signalling in rat GFSHR-17 granulosa cells: an in vitro model of granulosa cells in maturing follicles.
  7. P(2y2) and/or P(2y4) receptors may be involved in the enhanced purinergic signaling in lithium induced nephrogenic diabetes insipidus
    Title: Potential role of purinergic signaling in lithium-induced nephrogenic diabetes insipidus.
  8. expression of P2Y(4) receptors on rod bipolar cell axon terminals is reduced following dark adaptation, suggesting receptor expression may be dependent on retinal activity.
    Title: Localization and possible function of P2Y(4) receptors in the rodent retina.
  9. Cultured rat urothelial cells functionally express P2Y(2)/P2Y(4) receptors.
    Title: Expression and function of rat urothelial P2Y receptors.
  10. ATP analogs biphasically modulate the evoked release of glutamate from purified nerve terminals of the rat hippocampus, the inhibition being mediated by P2Y1, P2Y2, and/or P2Y4
    Title: Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled UTP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled UTP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within transepithelial chloride transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
P2Y purinoceptor 4
Names
P2Y ATP receptor 4
purinergic receptor P2Y, G-protein coupled 4
pyrimidinergic receptor P2Y, G-protein coupled, 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031680.1 → NP_113868.1  P2Y purinoceptor 4

    See identical proteins and their annotated locations for NP_113868.1

    Status: PROVISIONAL

    Source sequence(s)
    Y11433
    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    69722604..69757726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100015.2 → XP_038955943.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_039100012.2 → XP_038955940.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Related
    ENSRNOP00000082634.1
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_063280275.1 → XP_063136345.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78

  4. XM_039100009.2 → XP_038955937.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_039100014.2 → XP_038955942.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_039100011.2 → XP_038955939.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Related
    ENSRNOP00000094459.1
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. XM_063280274.1 → XP_063136344.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78

  8. XM_039100007.2 → XP_038955935.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  9. XM_063280276.1 → XP_063136346.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78

  10. XM_039100006.2 → XP_038955934.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  11. XM_063280273.1 → XP_063136343.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78

  12. XM_039100005.2 → XP_038955933.1  P2Y purinoceptor 4 isoform X1

    UniProtKB/Swiss-Prot
    O35811
    UniProtKB/TrEMBL
    A6IQ78
    Conserved Domains (1) summary
    cd15374
    Location:32 → 313
    7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35811.1 GenPept UniProtKB/Swiss-Prot:O35811

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