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SAA3P serum amyloid A3, pseudogene [ Homo sapiens (human) ]

Gene ID: 6290, updated on 10-Oct-2023

Summary

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Official Symbol
SAA3Pprovided by HGNC
Official Full Name
serum amyloid A3, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:10515
See related
Ensembl:ENSG00000290741 AllianceGenome:HGNC:10515
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAA3
Summary
Predicted to enable Toll-like receptor 4 binding activity and chemoattractant activity. Predicted to act upstream of or within several processes, including I-kappaB phosphorylation; cellular response to interleukin-1; and response to stilbenoid. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
11p15.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18112472..18116132, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18208017..18211675, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18134019..18137679, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene serum amyloid A like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4491 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 5 Neighboring gene MAS related GPR family member X3 Neighboring gene MAS related GPR family member X12, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Induction of human mammary-associated serum amyloid A3 expression by prolactin or lipopolysaccharide. Larson MA, et al. Biochem Biophys Res Commun, 2003 Feb 21. PMID 12589816
  2. The human serum amyloid A (SAA)-encoding gene GSAA1: nucleotide sequence and possible autocrine-collagenase-inducer function. Sack GH Jr, et al. Gene, 1989 Dec 14. PMID 2558975
  3. Nonexpression of the human serum amyloid A three (SAA3) gene. Kluve-Beckerman B, et al. DNA Cell Biol, 1991 Nov. PMID 1755958
  4. Localization of four human serum amyloid A (SAA) protein superfamily genes to chromosome 11p: characterization of a fifth SAA-related gene sequence. Sellar GC, et al. Genomics, 1993 Jun. PMID 8325654
  5. A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. Hansen MT, et al. Oncogene, 2015 Jan 22. PMID 24469032

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that long non-coding RNA MALAT1 regulates glucose-induced up-regulation of inflammatory mediators tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) through activation of serum amyloid antigen 3 (SAA3).
    Title: Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells.
  2. serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.
    Title: A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026576.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090099
    Related
    ENST00000534768.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18112472..18116132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18208017..18211675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002634.3: Suppressed sequence

    Description
    NG_002634.3: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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