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RPS6 ribosomal protein S6 [ Homo sapiens (human) ]

Gene ID: 6194, updated on 5-Jan-2025

Summary

Official Symbol
RPS6provided by HGNC
Official Full Name
ribosomal protein S6provided by HGNC
Primary source
HGNC:HGNC:10429
See related
Ensembl:ENSG00000137154 MIM:180460; AllianceGenome:HGNC:10429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S6; eS6
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 2180.7), bone marrow (RPKM 1555.2) and 25 other tissues See more
Orthologs
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Genomic context

See RPS6 in Genome Data Viewer
Location:
9p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (19375715..19380236, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (19388517..19393023, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (19375713..19380234, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19202444-19202962 Neighboring gene ribosomal protein S6 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19230483-19230989 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19230990-19231495 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:19233697-19233870 Neighboring gene DENN domain containing 4C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19250753-19251617 Neighboring gene uncharacterized LOC124902350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:19379549-19380748 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:19407977-19408834 and GRCh37_chr9:19408835-19409690 Neighboring gene alkaline ceramidase 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:19446057-19447256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28222

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S6 (RPS6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S6 (RPS6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S6 (RPS6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag HIV-1 Gag interacts with RPS6 as demonstrated by proximity dependent biotinylation proteomics and validated via immunoprecipitation and western blot analysis PubMed
gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S6 (RPS6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, ribosomal protein S6 (RPS6), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
matrix gag HIV-1 MA natural variant S75X induces the phosphorylation of AKT (S473), ERK1/2 (T202/Y204), and ribosomal protein S6 (S235/236) in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle  
involved_in T cell differentiation in thymus  
involved_in T cell proliferation involved in immune response  
involved_in TOR signaling PubMed 
involved_in activation-induced cell death of T cells  
involved_in cytoplasmic translation PubMed 
involved_in cytoplasmic translation PubMed 
involved_in cytoplasmic translation PubMed 
involved_in erythrocyte development  
involved_in gastrulation  
involved_in glucose homeostasis  
involved_in mammalian oogenesis stage  
involved_in negative regulation of apoptotic process  
involved_in placenta development  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in rRNA processing PubMed 
involved_in ribosomal small subunit biogenesis PubMed 
involved_in ribosomal small subunit biogenesis PubMed 
involved_in translation PubMed 
Items 1 - 20 of 21
Component Evidence Code Pubs
located_in cell body PubMed 
located_in cytoplasm PubMed 
located_in cytoplasmic ribonucleoprotein granule PubMed 
located_in cytosol  
located_in cytosol  
is_active_in cytosolic ribosome PubMed 
located_in cytosolic ribosome PubMed 
part_of cytosolic small ribosomal subunit PubMed 
part_of cytosolic small ribosomal subunit PubMed 
part_of cytosolic small ribosomal subunit PubMed 
located_in dendrite PubMed 
located_in endoplasmic reticulum  
located_in membrane PubMed 
located_in nucleolus PubMed 
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus PubMed 
located_in perinuclear region of cytoplasm  
part_of ribonucleoprotein complex PubMed 
part_of small ribosomal subunit PubMed 
part_of small-subunit processome PubMed 
Items 1 - 20 of 21

General protein information

Preferred Names
small ribosomal subunit protein eS6
Names
40S ribosomal protein S6
phosphoprotein NP33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010.3NP_001001.2  small ribosomal subunit protein eS6

    See identical proteins and their annotated locations for NP_001001.2

    Status: REVIEWED

    Source sequence(s)
    AL391834
    Consensus CDS
    CCDS6492.1
    UniProtKB/Swiss-Prot
    P08227, P10660, P62753, Q4VBY7, Q8N6Z7
    UniProtKB/TrEMBL
    A2A3R6, Q96DV6
    Related
    ENSP00000369757.4, ENST00000380394.9
    Conserved Domains (1) summary
    cl00931
    Location:1215
    Ribosomal_S6e; Ribosomal protein S6e

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    19375715..19380236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    19388517..19393023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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