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RPL9 ribosomal protein L9 [ Homo sapiens (human) ]

Gene ID: 6133, updated on 7-Apr-2024

Summary

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Official Symbol
RPL9provided by HGNC
Official Full Name
ribosomal protein L9provided by HGNC
Primary source
HGNC:HGNC:10369
See related
Ensembl:ENSG00000163682 MIM:603686; AllianceGenome:HGNC:10369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L9; uL6; NPC-A-16
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in ovary (RPKM 1269.0), bone marrow (RPKM 646.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (39454124..39458922, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (39423773..39428574, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (39455744..39460542, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 887, pseudogene Neighboring gene klotho beta Neighboring gene microRNA 5591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:39459543-39460293 Neighboring gene Sharpr-MPRA regulatory region 11886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21459 Neighboring gene lipoic acid synthetase Neighboring gene WD repeat domain 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9. Zhang H, et al. Proteins, 2021 Jul. PMID 33576138
  2. Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism. Lezzerini M, et al. Nucleic Acids Res, 2020 Jan 24. PMID 31799629, Free PMC Article
  3. Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication. Li Y, et al. Virology, 2016 Jan 15. PMID 26655239
  4. A new human ribosomal protein sequence, homologue of rat L9. Hori N, et al. Nucleic Acids Res, 1993 Sep 11. PMID 8415001, Free PMC Article
  5. Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis. Hassan FM, et al. Med Arch, 2021 Jun. PMID 34483448, Free PMC Article

See all (184) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.
    Title: Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.
  2. Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9.
    Title: Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9.
  3. Here we report an individual diagnosed with DBA carrying a variant in the 5'UTR of RPL9 (uL6). Additionally, we report two individuals from a family with multiple cancer incidences carrying a RPL9 missense variant
    Title: Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism.
  4. UNR could bind to the 3'UTR of PTEN and RPL9 in glioma cell lines, therefore promoting glioma cell migration and regulating the expression of RPL9.
    Title: RNA-binding Protein UNR Promotes Glioma Cell Migration and Regulates the Expression of Ribosomal Protein L9.
  5. High RPL9 expression is associated with colorectal carcinoma.
    Title: Knockdown of RPL9 expression inhibits colorectal carcinoma growth via the inactivation of Id-1/NF-ÎşB signaling axis.
  6. The authors propose that during rabies virus infection, viral phosphoprotein P binds to ribosomal protein L9 that translocates from the nucleus to the cytoplasm, inhibiting the initial stage of viral transcription.
    Title: Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L9 (RPL9) at amino acid residues 42-43 and 45-46 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ27456, MGC15545, DKFZp313J1510

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleus HDA PubMed 
located_in ribosome TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL6
Names
60S ribosomal protein L9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052985.1 RefSeqGene

    Range
    5027..9825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1142

mRNA and Protein(s)

  1. NM_000661.5 → NP_000652.2  large ribosomal subunit protein uL6

    See identical proteins and their annotated locations for NP_000652.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and the predominant variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC031906, BC066318, BM841336
    Consensus CDS
    CCDS3452.1
    UniProtKB/Swiss-Prot
    P32969
    UniProtKB/TrEMBL
    A0A024R9U2, D6RAN4, Q53Z07
    Related
    ENSP00000346022.7, ENST00000295955.14
    Conserved Domains (1) summary
    cl30086
    Location:1 → 191
    Ribosomal_L6; Ribosomal protein L6

  2. NM_001024921.4 → NP_001020092.1  large ribosomal subunit protein uL6

    See identical proteins and their annotated locations for NP_001020092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternative splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL039355, AY376242, BC031906
    Consensus CDS
    CCDS3452.1
    UniProtKB/Swiss-Prot
    P32969
    UniProtKB/TrEMBL
    A0A024R9U2, D6RAN4, Q53Z07
    Related
    ENSP00000494697.1, ENST00000645496.2
    Conserved Domains (1) summary
    cl30086
    Location:1 → 191
    Ribosomal_L6; Ribosomal protein L6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    39454124..39458922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    39423773..39428574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32969.1 GenPept UniProtKB/Swiss-Prot:P32969

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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