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CAMK2A calcium/calmodulin dependent protein kinase II alpha [ Canis lupus familiaris (dog) ]

Gene ID: 612941, updated on 5-Mar-2024

Summary

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Official Symbol
CAMK2Aprovided by VGNC
Official Full Name
calcium/calmodulin dependent protein kinase II alphaprovided by VGNC
Primary source
VGNC:VGNC:38680
See related
Ensembl:ENSCAFG00845007828
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (59281664..59346612)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (58567052..58631982)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (59715947..59780872)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (59070398..59135346)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (59184686..59249804)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106558732 Neighboring gene arylsulfatase family member I Neighboring gene solute carrier family 6 member 7 Neighboring gene uncharacterized LOC119871532 Neighboring gene caudal type homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stringent time-dependent transregulation of calcium calmodulin kinase II (CaMKII) is implicated in anti-apoptotic control. Fährmann M, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996739
  2. Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents. Livshitz LM, et al. Am J Physiol Heart Circ Physiol, 2007 Jun. PMID 17277017, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stringent limitation of CaMKII autophosphorylation at T286/287 by transregulation and prevention of hyperphosphorylation seems to restrict apoptosis.
    Title: Stringent time-dependent transregulation of calcium calmodulin kinase II (CaMKII) is implicated in anti-apoptotic control.
  2. Calcium-calmodulin protein kinase II is involved in excitation-contraction coupling in the myocardium.
    Title: Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
Names
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
XP_005619356.1
XP_005619358.1
XP_038329879.1
XP_038329880.1
XP_038390971.1
XP_038390972.1
XP_038455268.1
XP_038455269.1
XP_038519579.1
XP_038519580.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    59281664..59346612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663651.1 → XP_038519579.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0M5D8, A0A8C0S5Z7, A0A8I3MXQ9
    Related
    ENSCAFP00845010709.1, ENSCAFT00845013798.1
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357 → 484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. XM_038663652.1 → XP_038519580.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I3NIS8, A0A8P0P882
    Related
    ENSCAFP00845010756.1, ENSCAFT00845013868.1
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    59070398..59135346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038473951.1 → XP_038329879.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357 → 484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. XM_038473952.1 → XP_038329880.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    59184686..59249804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038599340.1 → XP_038455268.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357 → 484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. XM_038599341.1 → XP_038455269.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    59715947..59780872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038535043.1 → XP_038390971.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0M5D8, A0A8C0S5Z7, A0A8I3MXQ9
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357 → 484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. XM_038535044.1 → XP_038390972.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I3NIS8, A0A8P0P882
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58567052..58631982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005619299.3 → XP_005619356.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_005619356.1

    UniProtKB/TrEMBL
    A0A8C0M5D8, A0A8C0S5Z7, A0A8I3MXQ9
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357 → 484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. XM_005619301.3 → XP_005619358.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_005619358.1

    UniProtKB/TrEMBL
    A0A8I3NIS8, A0A8P0P882
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
Nucleotide Protein
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