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MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 612902, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K2provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 2provided by VGNC
Primary source
VGNC:VGNC:42972
See related
Ensembl:ENSCAFG00845022523
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 19 NC_051823.1 (24536705..24630042)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 19 NC_006601.4 (23457614..23550900)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 19 NC_049240.1 (24567169..24660474)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 19 NC_049279.1 (23240311..23333600)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 19 NC_049760.1 (23434707..23529263)

Chromosome 19 - NC_051823.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153535 Neighboring gene malate dehydrogenase, mitochondrial-like Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene uncharacterized LOC119864468

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 2
XP_005631935.1
XP_013976895.1
XP_038281889.1
XP_038281891.1
XP_038281892.1
XP_038358096.1
XP_038358097.1
XP_038358098.1
XP_038420786.1
XP_038420787.1
XP_038420788.1
XP_038484882.1
XP_038484883.1
XP_038484884.1
XP_852274.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051823.1 Reference ROS_Cfam_1.0

    Range
    24536705..24630042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038425963.1 → XP_038281891.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JQT6
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  2. XM_038425961.1 → XP_038281889.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JQT6
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  3. XM_038425964.1 → XP_038281892.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JQT6, A0A8C0T9Q7, A0A8I3PPG7
    Related
    ENSCAFP00845031152.1, ENSCAFT00845039774.1
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:354 → 617
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049279.1 Alternate UMICH_Zoey_3.1

    Range
    23240311..23333600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038502169.1 → XP_038358097.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  2. XM_038502168.1 → XP_038358096.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  3. XM_038502170.1 → XP_038358098.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:354 → 617
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049760.1 Alternate UNSW_CanFamBas_1.0

    Range
    23434707..23529263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038628955.1 → XP_038484883.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  2. XM_038628954.1 → XP_038484882.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  3. XM_038628956.1 → XP_038484884.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:354 → 617
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049240.1 Alternate UU_Cfam_GSD_1.0

    Range
    24567169..24660474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038564859.1 → XP_038420787.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JQT6
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  2. XM_038564858.1 → XP_038420786.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JQT6
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  3. XM_038564860.1 → XP_038420788.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JQT6, A0A8C0T9Q7, A0A8I3PPG7
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:354 → 617
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006601.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23457614..23550900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014121420.3 → XP_013976895.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JQT6
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  2. XM_005631878.4 → XP_005631935.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_005631935.1

    UniProtKB/TrEMBL
    A0A8C0JQT6
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:355 → 618
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  3. XM_847181.6 → XP_852274.2  mitogen-activated protein kinase kinase kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JQT6, A0A8C0T9Q7, A0A8I3PPG7
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:354 → 617
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
Nucleotide Protein
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