U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PAK2 p21 (RAC1) activated kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 612814, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PAK2provided by VGNC
Official Full Name
p21 (RAC1) activated kinase 2provided by VGNC
Primary source
VGNC:VGNC:53081
See related
Ensembl:ENSCAFG00845030194
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 33
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (30018726..30108342)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (29798837..29887939)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (30473517..30563048)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (29795936..29906532)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (29850899..29940690)

Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene ras-related protein Rab-5A-like Neighboring gene centrosomal protein 19 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class X Neighboring gene uncharacterized LOC111093719 Neighboring gene SUMO specific peptidase 5 Neighboring gene uncharacterized LOC119867353

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells. Gopal SK, et al. Oncotarget, 2016 Apr 12. PMID 26919098, Free PMC Article
  2. Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands. Klopfleisch R, et al. Res Vet Sci, 2009 Aug. PMID 19185891
  3. p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction. Yan X, et al. J Biol Chem, 2012 Apr 20. PMID 22393057, Free PMC Article
  4. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation. Whalley HJ, et al. Nat Commun, 2015 Jun 16. PMID 26078008, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate exosomal Rac1/PAK2 as angiogenic promoters.
    Title: Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells.
  2. Pak1 and Pak2 counteract centrosome separation in a kinase-dependent manner.
    Title: Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.
  3. PAK2 negatively modulate TGF-beta signaling by attenuating the receptor-Smad interaction and thus Smad activation
    Title: p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction.
  4. Taken together the results suggest that loss of p21 overexpression is associated with tumor metastasis while reduced cell cycle inhibition by p27 is associated with malignant progression.
    Title: Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase PAK 2
Names
p21 (CDKN1A)-activated kinase 2
XP_022269744.1
XP_038301216.1
XP_038301217.1
XP_038318233.1
XP_038375451.1
XP_038439093.1
XP_038439094.1
XP_038503500.1
XP_038503501.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051837.1 Reference ROS_Cfam_1.0

    Range
    30018726..30108342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445288.1 → XP_038301216.1  serine/threonine-protein kinase PAK 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q5W6, A0A8I3QE11, A0A8P0NEW1, A0A8P0NZF3
    Related
    ENSCAFP00845042109.1, ENSCAFT00845053588.1
    Conserved Domains (2) summary
    cd06655
    Location:229 → 524
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:73 → 130
    PBD; P21-Rho-binding domain

  2. XM_038445289.1 → XP_038301217.1  serine/threonine-protein kinase PAK 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q5W6, A0A8P0NEW1
    Conserved Domains (2) summary
    cd06655
    Location:183 → 478
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:27 → 84
    PBD; P21-Rho-binding domain

RNA

  1. XR_005306444.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049293.1 Alternate UMICH_Zoey_3.1

    Range
    29795936..29906532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519523.1 → XP_038375451.1  serine/threonine-protein kinase PAK 2 isoform X3

    Conserved Domains (2) summary
    cd06655
    Location:229 → 524
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:73 → 130
    PBD; P21-Rho-binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

    Range
    29850899..29940690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647572.1 → XP_038503500.1  serine/threonine-protein kinase PAK 2 isoform X1

    Conserved Domains (2) summary
    cd06655
    Location:229 → 524
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:73 → 130
    PBD; P21-Rho-binding domain

  2. XM_038647573.1 → XP_038503501.1  serine/threonine-protein kinase PAK 2 isoform X2

RNA

  1. XR_005417101.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

    Range
    30473517..30563048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583165.1 → XP_038439093.1  serine/threonine-protein kinase PAK 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NYX4, A0A8C0P8J5, A0A8C0QU98
    Conserved Domains (2) summary
    cd06655
    Location:229 → 524
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:73 → 130
    PBD; P21-Rho-binding domain

  2. XM_038583166.1 → XP_038439094.1  serine/threonine-protein kinase PAK 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0P8J5

RNA

  1. XR_005383423.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    29798837..29887939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038462305.1 → XP_038318233.1  serine/threonine-protein kinase PAK 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q5W6, A0A8I3QE11, A0A8P0NEW1, A0A8P0NZF3
    Conserved Domains (2) summary
    cd06655
    Location:229 → 524
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:73 → 130
    PBD; P21-Rho-binding domain

  2. XM_022414036.2 → XP_022269744.1  serine/threonine-protein kinase PAK 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q5W6, A0A8P0NEW1
    Conserved Domains (2) summary
    cd06655
    Location:183 → 478
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:27 → 84
    PBD; P21-Rho-binding domain

RNA

  1. XR_005317154.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous