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CBLC Cbl proto-oncogene C [ Canis lupus familiaris (dog) ]

Gene ID: 612343, updated on 5-Mar-2024

Summary

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Official Symbol
CBLCprovided by VGNC
Official Full Name
Cbl proto-oncogene Cprovided by VGNC
Primary source
VGNC:VGNC:38760
See related
Ensembl:ENSCAFG00845006988
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (111153520..111169844, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (110071648..110088645, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (111299843..111316680, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (110794862..110811626, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (110430583..110447333, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene nectin-2-like Neighboring gene basal cell adhesion molecule Neighboring gene uncharacterized LOC111097911 Neighboring gene uncharacterized LOC119870967 Neighboring gene BCL3 transcription coactivator Neighboring gene CEA cell adhesion molecule 16, tectorial membrane component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-C; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-C
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Cbl proto-oncogene, E3 ubiquitin protein ligase C
XP_005616520.1
XP_005616522.1
XP_038286409.1
XP_038323837.1
XP_038384550.1
XP_038384551.1
XP_038384552.1
XP_038448835.1
XP_038448836.1
XP_038448837.1
XP_038512639.1
XP_038512640.1
XP_038512641.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    111153520..111169844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038656711.1 → XP_038512639.1  E3 ubiquitin-protein ligase CBL-C isoform X1

    UniProtKB/TrEMBL
    A0A8C0KIT1, A0A8I3N747
    Related
    ENSCAFP00845009706.1, ENSCAFT00845012415.1
    Conserved Domains (6) summary
    cd09920
    Location:226 → 322
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PLN02915
    Location:349 → 449
    PLN02915; cellulose synthase A [UDP-forming], catalytic subunit
    cd00162
    Location:351 → 389
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam02262
    Location:16 → 142
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:149 → 232
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cl17238
    Location:333 → 397
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_038656712.1 → XP_038512640.1  E3 ubiquitin-protein ligase CBL-C isoform X2

    Conserved Domains (6) summary
    cd09920
    Location:152 → 248
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PLN02915
    Location:275 → 375
    PLN02915; cellulose synthase A [UDP-forming], catalytic subunit
    cd00162
    Location:277 → 315
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam02262
    Location:43 → 68
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:75 → 158
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cl17238
    Location:259 → 323
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_038656713.1 → XP_038512641.1  E3 ubiquitin-protein ligase CBL-C isoform X3

    Conserved Domains (4) summary
    cd09920
    Location:226 → 322
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02262
    Location:16 → 142
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:149 → 232
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cl17238
    Location:333 → 379
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    110794862..110811626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038467909.1 → XP_038323837.1  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-C isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    110430583..110447333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038592907.1 → XP_038448835.1  E3 ubiquitin-protein ligase CBL-C isoform X1

  2. XM_038592908.1 → XP_038448836.1  E3 ubiquitin-protein ligase CBL-C isoform X2

    Conserved Domains (6) summary
    cd09920
    Location:152 → 248
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PLN02915
    Location:275 → 375
    PLN02915; cellulose synthase A [UDP-forming], catalytic subunit
    cd00162
    Location:277 → 315
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam02262
    Location:43 → 68
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:75 → 158
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cl17238
    Location:259 → 323
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_038592909.1 → XP_038448837.1  E3 ubiquitin-protein ligase CBL-C isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    111299843..111316680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038528622.1 → XP_038384550.1  E3 ubiquitin-protein ligase CBL-C isoform X1

    UniProtKB/TrEMBL
    A0A8C0KIT1

  2. XM_038528623.1 → XP_038384551.1  E3 ubiquitin-protein ligase CBL-C isoform X2

    Conserved Domains (6) summary
    cd09920
    Location:152 → 248
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PLN02915
    Location:275 → 375
    PLN02915; cellulose synthase A [UDP-forming], catalytic subunit
    cd00162
    Location:277 → 315
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam02262
    Location:43 → 68
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:75 → 158
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cl17238
    Location:259 → 323
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_038528624.1 → XP_038384552.1  E3 ubiquitin-protein ligase CBL-C isoform X3

    Conserved Domains (4) summary
    cd09920
    Location:226 → 322
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02262
    Location:16 → 142
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:149 → 232
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cl17238
    Location:333 → 379
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    110071648..110088645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005616463.2 → XP_005616520.1  E3 ubiquitin-protein ligase CBL-C isoform X1

    UniProtKB/TrEMBL
    A0A8C0KIT1, A0A8C0LXC3, A0A8P0SA92
    Conserved Domains (4) summary
    cd09920
    Location:226 → 322
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:351 → 393
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02262
    Location:21 → 145
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:149 → 232
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_038430481.1 → XP_038286409.1  E3 ubiquitin-protein ligase CBL-C isoform X2

    Conserved Domains (6) summary
    cd09920
    Location:152 → 248
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PLN02915
    Location:275 → 375
    PLN02915; cellulose synthase A [UDP-forming], catalytic subunit
    cd00162
    Location:277 → 315
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam02262
    Location:43 → 68
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:75 → 158
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cl17238
    Location:259 → 323
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_005616465.3 → XP_005616522.1  E3 ubiquitin-protein ligase CBL-C isoform X3

    Conserved Domains (4) summary
    cd09920
    Location:226 → 322
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02262
    Location:21 → 145
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:149 → 232
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    pfam13923
    Location:351 → 378
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
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