MAP2K2 mitogen-activated protein kinase kinase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MAP2K2provided by VGNC
Official Full Name: mitogen-activated protein kinase kinase 2provided by VGNC
Primary source: VGNC:VGNC:110517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (56128646..56148204)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (55191875..55213954)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (55862931..55885022)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (55182690..55204761)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (55664143..55686194)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDGFbetaR was expressed and hyperphosphorylated in the majority of tumour samples and tumour derived cell lines. Additionally, both MEK and ERK were expressed and activated in cell lines as well as biopsies.
Title: Expression and activation of platelet-derived growth factor β receptor, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) and extracellular signal-regulated kinase (ERK) in canine mammary tumours.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 2

Names: ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2

NP_001041601.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048136.2 → NP_001041601.1 dual specificity mitogen-activated protein kinase kinase 2

See identical proteins and their annotated locations for NP_001041601.1

Status: VALIDATED

Source sequence(s)

AAEX03012569, CX987990, DN412923, DQ489531

UniProtKB/Swiss-Prot

Q1HG70

UniProtKB/TrEMBL

A0A8C0L1A1, A0A8C0QAL6, A0A8P0NXD8

Conserved Domains (1) summary

cd06649
Location:66 → 396

PKc_MEK2; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2