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SMAD3 SMAD family member 3 [ Canis lupus familiaris (dog) ]

Gene ID: 610902, updated on 5-Mar-2024

Summary

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Official Symbol
SMAD3provided by VGNC
Official Full Name
SMAD family member 3provided by VGNC
Primary source
VGNC:VGNC:46520
See related
Ensembl:ENSCAFG00845016639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
Madh3
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 30
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (31444224..31557937)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (31175971..31289442)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (31673713..31787293)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (31371657..31485227)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (31431846..31545247)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866923 Neighboring gene SMAD family member 6 Neighboring gene uncharacterized LOC111093346 Neighboring gene uncharacterized LOC119866924 Neighboring gene alpha and gamma adaptin binding protein Neighboring gene IQ motif containing H Neighboring gene uncharacterized LOC102152596

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of canine Smad3. Sugiyama K, et al. Biochem Genet, 2010 Apr. PMID 20221813
  2. IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation. Lin CS, et al. Cytokine, 2013 Jun. PMID 23579028

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-6 markedly decreased the nuclear concentration of a TGF-beta signaling transducer, Smad 2/3.
    Title: IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation.
  2. The carboxyl terminal amino acid of canine Smad3 is not unique, although it is unknown in the Boxer breed.
    Title: Nucleotide sequence of canine Smad3.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170829.3 → NP_001164300.3  mothers against decapentaplegic homolog 3

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000365
    UniProtKB/TrEMBL
    A0A8C0K4R2, A0A8C0N781, A0A8C0TUT2, A0A8I3P2U7, D2YYC0
    Related
    ENSCAFP00845023256.1, ENSCAFT00845029611.1
    Conserved Domains (2) summary
    cd10491
    Location:8 → 132
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:224 → 414
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    31444224..31557937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441750.1 → XP_038297678.1  mothers against decapentaplegic homolog 3 isoform X2

    Conserved Domains (2) summary
    cd10985
    Location:119 → 309
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:1 → 27
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. XM_038441749.1 → XP_038297677.1  mothers against decapentaplegic homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NW17
    Conserved Domains (2) summary
    cd10985
    Location:211 → 401
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:56 → 119
    MH1; N-terminal Mad Homology 1 (MH1) domain

  3. XM_038441751.1 → XP_038297679.1  mothers against decapentaplegic homolog 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MMU1, A0A8P0P8P9
    Conserved Domains (1) summary
    cd10985
    Location:29 → 219
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    31371657..31485227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    31431846..31545247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    31673713..31787293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    31175971..31289442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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