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ACE angiotensin I converting enzyme [ Canis lupus familiaris (dog) ]

Gene ID: 610668, updated on 5-Mar-2024

Summary

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Official Symbol
ACEprovided by VGNC
Official Full Name
angiotensin I converting enzymeprovided by VGNC
Primary source
VGNC:VGNC:97183
See related
Ensembl:ENSCAFG00845018336
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
DCP1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
26
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (13160704..13179888)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (12457866..12477045)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (15410134..15429354, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (12105344..12124523)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (15407255..15426429, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene cytochrome b561 Neighboring gene uncharacterized LOC111097319 Neighboring gene angiotensin-converting enzyme-like protein Ace3 Neighboring gene potassium voltage-gated channel subfamily H member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease. Meurs KM, et al. Pharmacogenet Genomics, 2018 Feb. PMID 29200408
  2. Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism. Meurs KM, et al. J Renin Angiotensin Aldosterone Syst, 2017 Oct-Dec. PMID 29069972, Free PMC Article
  3. An SNP within the angiotensin-converting enzyme distinguishes between sprint and distance performing Alaskan sled dogs in a candidate gene analysis. Huson HJ, et al. J Hered, 2011 Sep-Oct. PMID 21846742, Free PMC Article
  4. Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: a comprehensive study of all its components in the dog. Lee YA, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855304, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dogs with the ACE variant had lower levels of ACE activity even in more advanced mitral valve disease than dogs without the variant. The clinical significance of this finding and its impact on the need for ACE-I in dogs with the polymorphism and heart disease deserves further study
    Title: Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease.
  2. An ACE polymorphism is associated with lower levels of ACE activity.
    Title: Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism.
  3. An SNP within the angiotensin-converting enzyme distinguishes between sprint and distance performing Alaskan sled dogs in a candidate gene analysis.
    Title: An SNP within the angiotensin-converting enzyme distinguishes between sprint and distance performing Alaskan sled dogs in a candidate gene analysis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
angiotensin-converting enzyme
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
angiotensin I converting enzyme 1
angiotensin converting enzyme
XP_003639297.2
XP_038341044.1
XP_038341045.1
XP_038402852.1
XP_038402853.1
XP_038466823.1
XP_038466824.1
XP_038483107.1
XP_038531884.1
XP_038531885.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    13160704..13179888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038675956.1 → XP_038531884.1  angiotensin-converting enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8C0RHV4, A0A8C0SLR7, A0A8P0NF47
    Related
    ENSCAFP00845025906.1, ENSCAFT00845033094.1
    Conserved Domains (1) summary
    pfam01401
    Location:652 → 1230
    Peptidase_M2; Angiotensin-converting enzyme

  2. XM_038675957.1 → XP_038531885.1  angiotensin-converting enzyme isoform X2

    UniProtKB/TrEMBL
    A0A8C0SPL2
    Related
    ENSCAFP00845026027.1, ENSCAFT00845033244.1
    Conserved Domains (1) summary
    pfam01401
    Location:74 → 652
    Peptidase_M2; Angiotensin-converting enzyme

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    12105344..12124523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485116.1 → XP_038341044.1  angiotensin-converting enzyme isoform X1

    Conserved Domains (1) summary
    pfam01401
    Location:652 → 1230
    Peptidase_M2; Angiotensin-converting enzyme

  2. XM_038485117.1 → XP_038341045.1  angiotensin-converting enzyme isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    15407255..15426429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038610895.1 → XP_038466823.1  angiotensin-converting enzyme isoform X1

    Conserved Domains (1) summary
    pfam01401
    Location:652 → 1230
    Peptidase_M2; Angiotensin-converting enzyme

  2. XM_038610896.1 → XP_038466824.1  angiotensin-converting enzyme isoform X2

    Conserved Domains (1) summary
    pfam01401
    Location:74 → 652
    Peptidase_M2; Angiotensin-converting enzyme

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    15410134..15429354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038546924.1 → XP_038402852.1  angiotensin-converting enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8C0SLR7, A0A8P0NF47

  2. XM_038546925.1 → XP_038402853.1  angiotensin-converting enzyme isoform X2

    UniProtKB/TrEMBL
    A0A8C0SPL2
    Conserved Domains (1) summary
    pfam01401
    Location:74 → 652
    Peptidase_M2; Angiotensin-converting enzyme

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    12457866..12477045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003639249.5 → XP_003639297.2  angiotensin-converting enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8C0RHV4, A0A8C0SLR7, A0A8P0NF47
    Conserved Domains (1) summary
    pfam01401
    Location:652 → 1230
    Peptidase_M2; Angiotensin-converting enzyme

  2. XM_038627179.1 → XP_038483107.1  angiotensin-converting enzyme isoform X2

    UniProtKB/TrEMBL
    A0A8C0SPL2
    Conserved Domains (1) summary
    pfam01401
    Location:74 → 652
    Peptidase_M2; Angiotensin-converting enzyme
Nucleotide Protein
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