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NOTCH3 notch receptor 3 [ Canis lupus familiaris (dog) ]

Gene ID: 610439, updated on 5-Mar-2024

Summary

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Official Symbol
NOTCH3provided by VGNC
Official Full Name
notch receptor 3provided by VGNC
Primary source
VGNC:VGNC:43899
See related
Ensembl:ENSCAFG00845018638
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
33
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (47433115..47466250)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (46794145..46827285)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (47358143..47391299)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (46667867..46700947)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (47084556..47117682)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene epoxide hydrolase 3 Neighboring gene uncharacterized LOC119864725 Neighboring gene uncharacterized LOC119864724 Neighboring gene olfactory receptor 10T2-like Neighboring gene uncharacterized LOC100684131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurogenic locus notch homolog protein 3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3
Names
Notch homolog 3
notch 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    47433115..47466250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428355.1 → XP_038284283.1  neurogenic locus notch homolog protein 3

    UniProtKB/TrEMBL
    A0A8C0K7F9, A0A8C0PAF0, A0A8I3P150, A0A8P0SK77
    Related
    ENSCAFP00845025808.1, ENSCAFT00845032981.1
    Conserved Domains (11) summary
    smart00004
    Location:1424 → 1461
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:657 → 686
    EGF_CA; Calcium-binding EGF-like domain
    PHA03247
    Location:2030 → 2321
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1861 → 2027
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:158 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1908 → 1939
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1474 → 1503
    Notch; LNR domain
    pfam06816
    Location:1511 → 1563
    NOD; NOTCH protein
    pfam07684
    Location:1581 → 1640
    NODP; NOTCH protein
    pfam11936
    Location:2215 → 2275
    DUF3454; Domain of unknown function (DUF3454)
    cd21704
    Location:1621 → 1712
    JMTM_Notch3; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    46667867..46700947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038503997.1 → XP_038359925.1  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    47084556..47117682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631166.1 → XP_038487094.1  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3

    Conserved Domains (11) summary
    smart00004
    Location:1424 → 1461
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:657 → 686
    EGF_CA; Calcium-binding EGF-like domain
    PHA03247
    Location:2030 → 2321
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1861 → 2027
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:158 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1908 → 1939
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1474 → 1503
    Notch; LNR domain
    pfam06816
    Location:1511 → 1563
    NOD; NOTCH protein
    pfam07684
    Location:1581 → 1640
    NODP; NOTCH protein
    pfam11936
    Location:2215 → 2275
    DUF3454; Domain of unknown function (DUF3454)
    cd21704
    Location:1621 → 1712
    JMTM_Notch3; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    47358143..47391299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038567021.1 → XP_038422949.1  neurogenic locus notch homolog protein 3

    UniProtKB/TrEMBL
    A0A8C0K7F9, A0A8C0PAF0, A0A8I3P150, A0A8P0SK77
    Conserved Domains (11) summary
    smart00004
    Location:1424 → 1461
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:657 → 686
    EGF_CA; Calcium-binding EGF-like domain
    PHA03247
    Location:2030 → 2321
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1861 → 2027
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:158 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1908 → 1939
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1474 → 1503
    Notch; LNR domain
    pfam06816
    Location:1511 → 1563
    NOD; NOTCH protein
    pfam07684
    Location:1581 → 1640
    NODP; NOTCH protein
    pfam11936
    Location:2215 → 2275
    DUF3454; Domain of unknown function (DUF3454)
    cd21704
    Location:1621 → 1712
    JMTM_Notch3; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    46794145..46827285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022407359.2 → XP_022263067.2  neurogenic locus notch homolog protein 3

    UniProtKB/TrEMBL
    A0A8C0K7F9, A0A8C0PAF0, A0A8I3P150, A0A8P0SK77
    Conserved Domains (11) summary
    smart00004
    Location:1424 → 1461
    NL; Domain found in Notch and Lin-12
    smart00179
    Location:657 → 686
    EGF_CA; Calcium-binding EGF-like domain
    PHA03247
    Location:2030 → 2321
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1861 → 2027
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:158 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1908 → 1939
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1474 → 1503
    Notch; LNR domain
    pfam06816
    Location:1511 → 1563
    NOD; NOTCH protein
    pfam07684
    Location:1581 → 1640
    NODP; NOTCH protein
    pfam11936
    Location:2215 → 2275
    DUF3454; Domain of unknown function (DUF3454)
    cd21704
    Location:1621 → 1712
    JMTM_Notch3; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins
Nucleotide Protein
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