IGF1 insulin like growth factor 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IGF1provided by VGNC
Official Full Name: insulin like growth factor 1provided by VGNC
Primary source: VGNC:VGNC:41895
See related: Ensembl:ENSCAFG00845009366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: IGFI; IGF-I; IGFIA
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	15	NC_051819.1 (41855737..41930681, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	15	NC_006597.4 (41571399..41643792, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	15	NC_049236.1 (41495479..41567874, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	15	NC_049275.1 (41124961..41197284, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	15	NC_049756.1 (41221486..41300498, complement)

Chromosome 15 - NC_051819.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

""Immunolocalization and effect of low concentrations of Insulin like growth factor-1 (IGF-1) in the canine ovary"".
Title: "Immunolocalization and effect of low concentrations of Insulin like growth factor-1 (IGF-1) in the canine ovary".
Estrous detection with an activity and rumination monitoring system in an organic grazing and a low-input conventional dairy herd.
Title: Estrous detection with an activity and rumination monitoring system in an organic grazing and a low-input conventional dairy herd.
gene and protein expression of IGF1 and its receptor (IGF1R) in preovulatory follicles and in the CL of pregnant and non-pregnant dogs, were examined.
Title: Expression of insulin-like growth factor 1 and its receptor in preovulatory follicles and in the corpus luteum in the bitch.
This study suggested that serum 26SP concentrations seem to be increased in some dogs suffering from malignant tumors, especially in dogs with mammary carcinoma and smaller tumors and that increased serum IGF-1 concentrations could be an indication of large tumors and a poor prognosis.
Title: 26S proteasome and insulin-like growth factor-1 in serum of dogs suffering from malignant tumors.
Leptin and insulin like growth factor 1 may support spermatogenesis in adult dogs and mediate Leydig cell function
Title: Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs.
This study evaluated the role of IGF1 and phosphoinositol 3 kinase signaling in the pathogenesis of adrenocortical tumors in dogs and to identify pathway components that may hold promise as future therapeutic targets or as prognostic markers.
Title: Insulin-like growth factor--phosphatidylinositol 3 kinase signaling in canine cortisol-secreting adrenocortical tumors.
These data strongly indicated a strong relathionship between fetal fluids IGF-I and nonesterified fatty acid concentrations and breed size exists.
Title: IGF-I and NEFA concentrations in fetal fluids of term pregnancy dogs.
This study found that serum protein profiles and IGF-I concentrations were altered in both diabetic and insulin-treated animals.
Title: Evaluation of IGF-I levels and serum protein profiles of diabetic cats and dogs.
There was significantly higher expression of genes encoding for growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in metastases compared to their primary tumours.
Title: Expression of insulin-like growth factor-1 by canine insulinomas and their metastases.
This study focuses on the co-expression of interleukin-4 (IL-4) and insulin-like-growth factor-1 (IGF-1), which specifically target inflammation and cartilage repair, respectively.
Title: Co-expression of insulin-like growth factor-1 and interleukin-4 in an in vitro inflammatory model.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:482382

Igf1 (e-PCR), detects polymorphism
- UniSTS:516198

Igf1 (e-PCR), detects polymorphism
- UniSTS:143467

IGF1 (e-PCR), detects polymorphism
- UniSTS:264067

Igf1 (e-PCR), detects polymorphism
- UniSTS:516546

IGF1 (e-PCR), detects polymorphism
- UniSTS:506314

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: insulin-like growth factor I

Names: somatomedin C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313855.1 → NP_001300784.1 insulin-like growth factor I precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000372

UniProtKB/Swiss-Prot

P33712

UniProtKB/TrEMBL

A0A8C0LJP4, A0A8C0SW86

Related

ENSCAFP00845012869.1, ENSCAFT00845016544.1

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051819.1 Reference ROS_Cfam_1.0

Range

41855737..41930681 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038687204.1 → XP_038543132.1 insulin-like growth factor I isoform X3

UniProtKB/TrEMBL

A0A8C0LGN3, A0A8C0SXI4, A0A8I3NN66

Related

ENSCAFP00845012913.1, ENSCAFT00845016603.1

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_038687205.1 → XP_038543133.1 insulin-like growth factor I isoform X4

UniProtKB/TrEMBL

A0A8C0MW23, A0A8I3N8M8, A0A8P0PGD5

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_038687203.1 → XP_038543131.1 insulin-like growth factor I isoform X2

UniProtKB/TrEMBL

A0A8C0SXH2, A0A8C0SXL0, A0A8I3NBK5, A0A8I3NBV2

Related

ENSCAFP00845012965.1, ENSCAFT00845016662.1

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_038687202.1 → XP_038543130.1 insulin-like growth factor I isoform X1

UniProtKB/TrEMBL

A0A8C0SXH2, A0A8I3NBV2

Related

ENSCAFP00845012938.1, ENSCAFT00845016630.1

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...