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JAK3 Janus kinase 3 [ Canis lupus familiaris (dog) ]

Gene ID: 610004, updated on 11-Apr-2024

Summary

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Official Symbol
JAK3provided by VGNC
Official Full Name
Janus kinase 3provided by VGNC
Primary source
VGNC:VGNC:42177
See related
Ensembl:ENSCAFG00845024918
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (45535925..45553392)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (44963131..44980402)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (45459016..45476242)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (44772769..44789998)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (45183055..45200281)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 5 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene ribosomal protein L18a Neighboring gene insulin like 3 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK3
Names
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
XP_005632774.2
XP_013977870.1
XP_038284135.1
XP_038284136.1
XP_038284137.1
XP_038311635.1
XP_038311636.1
XP_038359788.1
XP_038359789.1
XP_038359790.1
XP_038422805.1
XP_038422806.1
XP_038422807.1
XP_038486958.1
XP_038486959.1
XP_038486960.1
XP_038486961.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    45535925..45553392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428207.1 → XP_038284135.1  tyrosine-protein kinase JAK3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KFC8, A0A8C0NQM4, A0A8I3S4Z2
    Related
    ENSCAFP00845034660.1, ENSCAFT00845044226.1
    Conserved Domains (5) summary
    pfam18377
    Location:126 → 245
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:41 → 112
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:362 → 458
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:250 → 362
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:817 → 1099
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038428208.1 → XP_038284136.1  tyrosine-protein kinase JAK3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KFC8
    Conserved Domains (5) summary
    pfam18377
    Location:126 → 245
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:41 → 112
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:362 → 458
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:250 → 362
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:521 → 778
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038428209.1 → XP_038284137.1  tyrosine-protein kinase JAK3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KFC8
    Conserved Domains (4) summary
    pfam18377
    Location:1 → 73
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:190 → 286
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:78 → 190
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:645 → 927
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    44772769..44789998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038503860.1 → XP_038359788.1  tyrosine-protein kinase JAK3 isoform X1

    Conserved Domains (5) summary
    pfam18377
    Location:126 → 245
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:41 → 112
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:362 → 458
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:250 → 362
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:817 → 1099
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038503861.1 → XP_038359789.1  tyrosine-protein kinase JAK3 isoform X2

    Conserved Domains (5) summary
    pfam18377
    Location:126 → 245
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:41 → 112
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:362 → 458
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:250 → 362
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:521 → 778
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038503862.1 → XP_038359790.1  tyrosine-protein kinase JAK3 isoform X3

    Conserved Domains (4) summary
    pfam18377
    Location:1 → 73
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:190 → 286
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:78 → 190
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:645 → 927
    PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    45183055..45200281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631030.1 → XP_038486958.1  tyrosine-protein kinase JAK3 isoform X1

  2. XM_038631031.1 → XP_038486959.1  tyrosine-protein kinase JAK3 isoform X2

  3. XM_038631032.1 → XP_038486960.1  tyrosine-protein kinase JAK3 isoform X3

    Conserved Domains (4) summary
    pfam18377
    Location:1 → 73
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:190 → 286
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:78 → 190
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:645 → 927
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038631033.1 → XP_038486961.1  tyrosine-protein kinase JAK3 isoform X3

    Conserved Domains (4) summary
    pfam18377
    Location:1 → 73
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:190 → 286
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:78 → 190
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:645 → 927
    PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    45459016..45476242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038566877.1 → XP_038422805.1  tyrosine-protein kinase JAK3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KFC8, A0A8P0NSD5

  2. XM_038566878.1 → XP_038422806.1  tyrosine-protein kinase JAK3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KFC8

  3. XM_038566879.1 → XP_038422807.1  tyrosine-protein kinase JAK3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KFC8
    Conserved Domains (4) summary
    pfam18377
    Location:1 → 73
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:190 → 286
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:78 → 190
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:645 → 927
    PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44963131..44980402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005632717.4 → XP_005632774.2  tyrosine-protein kinase JAK3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KFC8, A0A8P0NSD5
    Conserved Domains (5) summary
    smart00295
    Location:41 → 200
    B41; Band 4.1 homologues
    pfam07714
    Location:822 → 1095
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:362 → 458
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:250 → 362
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:817 → 1099
    PKc_like; Protein Kinases, catalytic domain

  2. XM_014122395.3 → XP_013977870.1  tyrosine-protein kinase JAK3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KFC8
    Conserved Domains (5) summary
    smart00295
    Location:41 → 200
    B41; Band 4.1 homologues
    pfam07714
    Location:822 → 1058
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:362 → 458
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:250 → 362
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:521 → 778
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038455707.1 → XP_038311635.1  tyrosine-protein kinase JAK3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KFC8
    Conserved Domains (4) summary
    pfam18377
    Location:1 → 73
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:190 → 286
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:78 → 190
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:645 → 927
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038455708.1 → XP_038311636.1  tyrosine-protein kinase JAK3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KFC8
    Conserved Domains (4) summary
    pfam18377
    Location:1 → 73
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl15255
    Location:190 → 286
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:78 → 190
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:645 → 927
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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